期刊
NEW JOURNAL OF CHEMISTRY
卷 40, 期 12, 页码 9923-9929出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nj01986b
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资金
- Anhui Institute of Medical Information
The encapsulation of paclitaxel (PTX) using amphiphilic calixarene (SC4-C-6) is an attempt to improve its water solubility. The optimized nanocapsules were successfully prepared by a thin film hydration method where an organic phase containing the mixture of PTX and SC4-C-6 (molar ratio of 1:10) was dispersed by probe sonication for 30 s into an aqueous phase. The optimized formulation of PTX loaded amphiphilic calix[4]arene nanocapsules had an average particle size of 206 +/- 14 nm and an encapsulation efficiency of 82.65 +/- 2.54%. Transmission electron micrographs demonstrated the sphere shape of the PTX loaded amphiphilic calix[4]arene formulation without obvious agglomeration. In vitro drug release experiments clarified the obvious sustained release behaviors of the PTX loaded amphiphilic calix[4]arene formulation compared to commercial Taxol. Furthermore, the PTX loaded SC4-C-6 formulation revealed improved PTX induced cytotoxicity in human cervical cancer cell culture experiments in contrast to Taxol. The nanocapsules assembled from amphiphilic calixarenes obtained in this work displayed a desired narrow size range with acceptable drug loading and sustained release behaviors, which are beneficial for their potential application as an anti-cancer drug delivery vehicle.
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