期刊
NEW JOURNAL OF CHEMISTRY
卷 40, 期 7, 页码 6289-6298出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nj02979a
关键词
-
Starting from the proligand 2-[(6-methylpyridin-2-yl)] imidazo[1,5-a] pyridin-4-ylium hexafluorophosphate(1 center dot PF6), three new complexes, viz. [Au(1)(2)] [PF6] (2), [1/2AuCl(2), 1/2AuCl(4)](-) [(1H)](+) (3), and [Au(1)Cl-3] (4), have been synthesized and characterized employing different spectroscopic methods. [Au(1)Cl-3] (4) has been synthesized by the disproportionation process. During the transformation of 2 to 4, the annelated proligand stabilizes both Au(I) and Au(III), and the isolation of the intermediate (3) confirms the conversion of Au(I) - Au(III) through the disproportionation pathway. The solid state structures of 2, 3 and 4 have been determined. Linear geometry was observed in 2, whereas complex 4 adopted square-planar geometry. Gold complexes 2 and 4 have been subjected to growth inhibitory studies. Complex 2 induced apoptosis in HepG2 cells along with increased expression of proteins involved in the mitochondrial death pathway, suggesting that apoptosis may occur via the mitochondrial death pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据