期刊
NEW JOURNAL OF CHEMISTRY
卷 40, 期 8, 页码 6946-6954出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nj00288a
关键词
-
资金
- National Natural Science Foundation of China [21371087]
- Natural Science Foundation of Shandong Province [ZR2015BL001]
A novel 4-fluorobenzenetelluronic trimethyltin ester (Me3Sn)(4)[p-F-PhTe(mu-O)(OH)O-2](2) (1) has been prepared and fully characterized using elemental analysis, FT-IR, NMR (H-1, C-13, Sn-119) spectroscopy, XRD and X-ray crystallography. Structural analysis shows that the complex is crystallized as a Sn4Te2 molecule, in which an asymmetric four-membered Te-2(mu(2)-O)(2) unit is situated in the center. The geometry of tellurium is described as a distorted octahedron and for each tin it is described as a distorted tetrahedron. Underlying cytotoxic mechanisms involved in the apoptotic death of A549 cells upon exposure to the complex have been investigated and the results reveal that the anti-proliferative and proapoptotic effects of the complex in A549 cells prominently contributed to the accumulation of ROS, dysfunctional depolarization of the mitochondrial membrane and activation of caspase-3.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据