期刊
NEW JOURNAL OF CHEMISTRY
卷 40, 期 9, 页码 7513-7521出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nj00346j
关键词
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资金
- National Natural Science Foundation of China [21171101, 21471085, 21371135]
- MOE Innovation Team of China [IRT13022]
- PhD Research Startup Foundation of Shanxi Agricultural University [2013YJ40, 2013YJ41]
- Science and Technology Innovation Fund of Shanxi Agricultural University [2014005, 2014013]
- Science Foundation of Tianjin Medical University [2014KYM09]
Two new mononuclear zinc(II) complexes [ZnLX2](2) center dot CH3OH (X = Br for 1, Cl for 2) of a tridentate polypyridyl ligand L (L = 4-methyl-N,N-bis(pyridin-2-ylmethyl)aniline) have been synthesized and structurally characterized. The interactions of two complexes with CT-DNA, pBR322 plasmid DNA and BSA have been explored respectively by using various physico-chemical techniques. Furthermore, the anticancer activities of the complexes towards three human tumor cells lines (HeLa, MCF-7 and RL952) have been studied. The IC50 values of 1 (on MCF-7 cells) and 2 (on RL952 cells) are 12.58 mu M and 11.71 mu M, respectively. The apoptosis-inducing activity of 1 was assessed by Hoechst 33342 staining, Annexin V binding and cell cycle analyses.
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