Magnetic nanoparticles with chelating shells prepared by RAFT/MADIX polymerization

In this study, the preparation of multifunctional materials based on magnetic nanoparticles (MNP) and original thiosemicarbazide derivatives is presented. The synthesized nanohybrids consist of an iron oxide core and a polymeric shell, which possesses the ability to complex metal ions. They exhibit superparamagnetic properties and can thus be easily separated from complex mixtures using an external magnetic field (facile separation, purification, and recyclability). Synthesized carbamohydrazonothioate derivatives were polymerized on dithiocarbonate-coated MNPs using the RAFT/MADIX (reversible addition-fragmentation transfer/macromolecular design by interchange of xanthates) method. Three types of nanohybrids were obtained and their physicochemical properties were investigated. The ability of nanohybrids to complex palladium(II) ions and the spectroscopic properties of the obtained materials were studied. In addition, the hemolytic activity tests of polymer-coated particles were performed in order to confirm their potential in biomedical applications.