Metal complexes induced ferroptosis for anticancer therapy

Metal complexes for anti-tumor treatment have been developed rapidly in recent decades since the application of cisplatin in clinics. However, some tumor cells are resistant to apoptosis and not sensitive to metallodrugs that function through the apoptotic pathway. Recently, metal complexes have been reported to cause ferropto-sis against tumor cells, which offers new opportunities for anticancer therapy. In this perspective, ferroptosis-inducing metal complexes and their working mechanisms are introduced, while the challenges and opportunities are also discussed.

Automated summary

Metal complexes for anti-tumor treatment have developed rapidly, while some tumor cells are resistant to apoptosis and not sensitive to metallodrugs that function through the apoptotic pathway. Recently, metal complexes have been reported to induce ferroptosis against tumor cells, providing new opportunities for anticancer therapy. This perspective introduces ferroptosis-inducing metal complexes, their working mechanisms, and discusses the challenges and opportunities.