期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 242, 期 -, 页码 25-33出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2015.08.014
关键词
Emetine; p38; ERK; Metastasis; Matrix metalloproteinases; Human non-small-cell lung cancer
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology of Korea [2010-0023292]
- National Research Foundation of Korea [2010-0023292] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Emetine is a natural compound originated from ipecac roots. It was commonly used as anti-protozoal and vomiting agent. The apoptosis-inducing effect of emetine makes it considered as a potential anti-cancer agent for various human cancers. Here in this study, we report that emetine inhibits migration and invasion of human non-small-cell lung cancer (NSCLC) cells. Modulation of three major mitogen-activated protein kinases (MAPKs), ERR, p38 and JNK, is well known to be involved in regulation of matrix metalloproteinases (MMPs), which are essential in tissue remodeling and extracellular matrix (ECM) degradation, for cancer cells to spread out from the origin of tumorigenesis. Emetine regulates two major MAPKs, p38 and ERR. Differential inhibition/stimulation of ERR and p38 induced differential suppressions of beta-catenin and c-myc transcription factors. This leads to the selective down-regulation of MMP-2 and MMP-9, two major gelatinases which can degrade ECM components, and RECK, a negative regulator of MMP-9. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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