期刊
EGYPTIAN JOURNAL OF ANAESTHESIA
卷 39, 期 1, 页码 571-578出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/11101849.2023.2236866
关键词
Atropine; cardiac output; caesarean delivery; electrical cardiometry; spinal anesthesia
Spinal anesthesia for cesarean delivery often leads to hypotension, bradycardia, and reduced cardiac output. This study suggests that using atropine can effectively prevent post-spinal bradycardia and minimize the reduction in cardiac output.
Background: Spinal anesthesia is a widely used technique for cesarean delivery, but it often results in hypotension, bradycardia, and reduced cardiac output (CO). Atropine has a potent muscarinic receptor antagonist activity in the heart. It may be a good choice to prevent post-spinal bradycardia and minimize the marked CO reduction. Methods: Sixty pregnant women between the ages of 18 and 40 who were ASA-PS II and planned for elective cesarean delivery were divided into two equal groups at random. Both groups received spinal anesthesia. Atropine group (I) (n = 30): patients received 0.01 mg/kg atropine, while control group (II) (n = 30): patients received the sam e volume of saline. CO measured by electrical cardiometry (EC) was the primary outcome where, heart rate (HR), mean blood pressure (MBP), stroke volume (SV), systemic vascular resistance (SVR), and neonatal outcomes were the secondary outcomes. Results: CO after the intervention was higher in the atropine (group I) than in the control (group II). Also, CO reduction at 5 and 10 min following spinal anesthesia was less in the group I than in the group II. Except for baseline reading, HR was significantly higher in the atropine group versus the control group. MBP was higher in the atropine group than in the control group in all readings. SV and SVR were similar in both groups. Neonatal outco mes were equivalent in both groups. Conclusion: Pre-spinal atropine was effective in preventing post-spinal bradycardia and minimized CO reduction in patients undergoing elective cesarean delivery under spinal anesthesia.
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