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Article
Medicine, General & Internal
Barak Mizrahi et al.
Summary: This study suggests that patients with mild covid-19 may experience some clinical sequelae within a year after infection, but most of them resolve within a year. Age, sex, SARS-CoV-2 variants, and vaccination status are associated with the occurrence of these sequelae.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Pediatrics
Young Hwa Lee et al.
Summary: This study aimed to characterize the factors associated with COVID-19 transmission among students in Seoul, South Korea. The findings suggest that COVID-19 transmission is more influenced by the community burden among students compared to adults. Public health initiatives should prioritize protecting students from COVID-19 when the community carries a high burden of infection.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
Article
Immunology
Maria Zavala et al.
Summary: This study investigates the ongoing symptoms in children with COVID-19 and compares them with a symptomatic control group. The findings suggest that children with symptomatic COVID-19 have a slightly higher prevalence of ongoing symptoms compared to symptomatic controls. However, mental health symptoms were high and equally prevalent in both groups.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Luise Borch et al.
Summary: The study aimed to evaluate symptoms and duration of 'long COVID' in children. It found that most children recovered from symptoms within 1-5 months, suggesting that long COVID in children is rare and mainly of short duration.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Infectious Diseases
S. A. Behnood et al.
Summary: There is conflicting data on the long-term impact of SARS-CoV-2 infection in children and young people. This study assessed the evidence on long-term post-COVID symptoms in this population, including prevalence, risk factors, type, and duration. The findings suggest that the frequency of most reported persistent symptoms is similar in COVID-positive cases and controls.
JOURNAL OF INFECTION
(2022)
Review
Cell Biology
Aisha Tabassum et al.
Summary: Understanding the interaction between SARS-CoV-2, ACE2, bradykinin, and its metabolite des-Arg9-bradykinin is crucial in understanding the pathogenesis of COVID-19 and developing new treatment approaches.
MEDIATORS OF INFLAMMATION
(2022)
Article
Medicine, General & Internal
Karin Magnusson et al.
Summary: This study aimed to explore whether children and adolescents increased their use of healthcare services after the covid-19 pandemic and found that there was limited impact on healthcare services in Norway. Preschool-aged children might take longer to recover.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Biology
Valentina Fainardi et al.
Summary: Long-term COVID-19 in children may be a relevant clinical problem, with most cases having a good prognosis but some children experiencing long-term symptoms that significantly impact their daily life. The lack of research on long COVID in children, including a control group of uninfected children, prevents firm conclusions from being drawn. The cause of neuropsychiatric symptoms in children with long COVID is still unclear, but psychological support can play a fundamental role in managing the pandemic in children. More knowledge is needed to standardize the definition of the syndrome and improve its management and treatment.
Article
Allergy
Danilo Buonsenso et al.
Summary: Long COVID syndrome is characterized by persistent mild-to-moderate symptoms and medical complications after infection with SARS-CoV-2. This report proposes a model for the pathophysiology of long COVID, suggesting that the persistence of the virus or its molecular components leads to increased production of proinflammatory cytokines. This dysregulated immune response and chronic inflammation are hypothesized to form the basis of the syndrome.
ALLERGY AND ASTHMA PROCEEDINGS
(2022)
Article
Pediatrics
Terence Stephenson et al.
Summary: The objective of this study was to establish a research definition for 'Long COVID (post-COVID-19 condition)' in children and young people (CYP) to enable comparison of research studies. A three-phase online Delphi process and a consensus meeting were conducted. The research definition proposed includes a minimum duration of 12 weeks of persisting physical symptoms after initial testing, impacting everyday functioning and not explained by an alternative diagnosis, in young people with a history of confirmed SARS-CoV-2 infection. This is the first research definition of Long COVID in CYP and aligns with the clinical case definition proposed by the WHO.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Respiratory System
Ismail M. Osmanov et al.
Summary: This study aimed to assess the long-term outcomes in children previously hospitalized with COVID-19 and found that a quarter of children experienced persistent symptoms months after hospitalization. Older age and allergic diseases were associated with a higher risk of persistent symptoms at follow-up.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Microbiology
Danilo Buonsenso et al.
Summary: This study conducted a survey on children with persistent symptoms after initial infection and found that symptoms such as fatigue, headache, muscle and joint pain, rashes, heart palpitations, lack of concentration, and short-term memory problems were particularly common. There is an urgent need for a better understanding of long coronavirus disease.
FUTURE MICROBIOLOGY
(2022)
Review
Microbiology
Danilo Buonsenso et al.
Summary: The article analyzes the evidence on pediatric long covid and lessons learnt from a pediatric post-covid unit in Rome, Italy. It also examines the long-term effects of other infectious diseases. Understanding the potential long-term consequences of this novel infection is crucial, as long-term effects of post-infectious diseases are not new phenomena.
FUTURE MICROBIOLOGY
(2022)
Article
Pediatrics
Meera Beharry
Summary: This article discusses the importance of pediatricians in assessing and treating mental health issues such as anxiety and depression during the COVID-19 pandemic, as well as the impact of long-COVID on these conditions. Strategies and tools are provided to help pediatricians address the mental health needs of their patients.
Article
Medicine, General & Internal
Martin Roessler et al.
Summary: This study investigated the post-COVID-19 morbidity in children, adolescents, and adults using comprehensive healthcare data from Germany. The study found that individuals of all age groups are at risk of post-COVID-19 syndrome and the spectrum of health problems differs between age groups.
Article
Infectious Diseases
Maria Skaalum Petersen et al.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Lynn Eitner et al.
Summary: This study investigates the neurological symptoms in children and adolescents after SARS-CoV-2 infection. It found that approximately 33% of patients have persistent symptoms after infection. Neurological examinations showed increased detection thresholds for thermal and vibration stimuli in infected patients. Around 36% of patients displayed abnormal sensory function. This study provides evidence that the function of large or small nerve fibers in children and adolescents after SARS-CoV-2 infection may be reversibly impaired.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Soo-Han Choi et al.
Summary: COVID-19 is generally a mild to moderate respiratory illness in children and adolescents, but some may develop severe or critical illness. This review summarizes clinical data on antiviral agents and immunomodulators for COVID-19 treatment in children and adolescents. The article also discusses the current recommendations for therapeutics in this population. Remdesivir is suggested for pediatric patients with severe COVID-19 who require supplemental oxygen but not mechanical ventilation, as well as for adolescents aged ≥12 years and weighing at least 40 kg with COVID-19 without the need for supplemental oxygen and within 7 days of symptom onset and at high risk of progression to severe illness. Nirmatrelvir/ritonavir is considered for adolescents aged ≥12 years and weighing at least 40 kg without the need for supplemental oxygen and within 5 days of symptoms onset and at high risk of progression to severe disease. Corticosteroids are not recommended for children and adolescents with mild to moderate COVID-19, but are recommended for those with severe to critical COVID-19.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2022)
Review
Pediatrics
Bohyun Jin et al.
Summary: In Korea, although social distancing measures have helped to prevent the spread of the coronavirus to some extent, they have had negative effects on mental health, especially among adolescents. The restrictions on outdoor activities and increased parenting burden have led to increased screen time, symptoms of depression and anxiety. Additionally, children and adolescents are experiencing symptoms of posttraumatic stress disorder (PTSD) and somatization during the pandemic. The increased rates of child abuse during the pandemic, particularly emotional/psychological abuse and nonmedical neglect, are also a concerning issue.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2022)
Article
Pediatrics
Gokcen Kartal Ozturk et al.
Summary: The study found that some children may experience persistent respiratory symptoms after COVID-19 infection, regardless of disease severity, potentially due to inflammation affecting the peripheral airways.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Susanna Esposito et al.
Summary: This article discusses the current understanding of pediatric long COVID and how to identify and manage children with long COVID. The true prevalence of long COVID in pediatrics is not known, but it is recommended to evaluate the presence of symptoms suggestive of long COVID between 4 and 12 weeks after the acute phase of the disease. Symptoms such as persistent headache, fatigue, sleep disturbance, difficulty in concentrating, abdominal pain, myalgia, or arthralgia should raise suspicion of long COVID in children and adolescents.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Review
Virology
Jhilik Dey et al.
Summary: Due to the highly pathogenic nature of the novel coronavirus, SARS-CoV-2, it can affect the brain through various pathways, particularly through infection of the respiratory center leading to respiratory failure. Screening for neurological symptoms in COVID-19 patients may help better understand the disease.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Pediatrics
Jonas F. Ludvigsson
Summary: This study focuses on the persistent symptoms in five Swedish children post-COVID-19, indicating a lack of pediatric data on long COVID. Similarly to adults, children may also experience symptoms of long COVID with females potentially being more affected.
Article
Biochemistry & Molecular Biology
Lauren B. Rodda et al.
Summary: The study found that individuals recovered from mild COVID-19 develop sustained SARS-CoV-2-specific immunological memory for at least 3 months, including immunoglobulin antibodies, neutralizing plasma, and memory B and T cells. These memory lymphocytes exhibit potent antiviral function, aiding in immune defense.
Editorial Material
Pharmacology & Pharmacy
Cameron G. McCarthy et al.
VASCULAR PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shin Jie Yong
Summary: Long-COVID is a postviral illness that can affect survivors of COVID-19, potentially caused by long-term tissue damage, viral persistence, and dysfunction of the brainstem. The brainstem plays a crucial role in manifesting symptoms, including respiratory, cardiovascular, and neurological functions, thus potentially linking it to long-COVID.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Allergy
Jean Bousquet et al.
Summary: This article suggests that differences in COVID-19 morbidity may be associated with TRPA1 and TRPV1 activation and desensitization, potentially leading to inflammation and various symptoms. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may affect the severity of COVID-19 symptoms.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Pediatrics
Danilo Buonsenso et al.
Article
Pediatrics
Ieva Roge et al.
Summary: The study found that almost three-quarters of children reported at least one persistent symptom at the time of the interview, with the majority of patients (53%) having two or more concurrent symptoms. The inclusion of a comparison group allowed the researchers to identify that symptom persistence is more apparent with COVID-19 than any other non-SARS-CoV-2 infection. Further research is needed to distinguish the symptoms of long COVID from pandemic-associated complaints. Each persistent symptom is important in terms of child well-being during COVID-19 recovery.
FRONTIERS IN PEDIATRICS
(2021)
Review
Medicine, General & Internal
Filippo Liviero et al.
Summary: This study explores the role of the TRPV-1 channel in the infection, susceptibility, pathogenesis, and treatment of COVID-19, suggesting the use of TRPV-1 agonists for improving lung function and clearing infections as a novel strategy.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Pediatrics
Ellinor Sterky et al.
Article
Biochemistry & Molecular Biology
Sahar M. Jaffal et al.
Summary: COVID-19, caused by SARS-CoV-2, may involve TRP channels, which could play a role in symptoms such as pneumonia, respiratory issues, and pain. Targeting TRP channels could be a potential therapeutic approach for COVID-19.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Letter
Medicine, General & Internal
Thomas Radtke et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pediatrics
Caroline L. H. Brackel et al.
Summary: A survey of Dutch pediatricians identified 89 children aged 2-18 suspected of long-COVID, with 36% experiencing severe limitations in daily function. Common symptoms include fatigue, dyspnea, and concentration difficulties. The study emphasizes the need for a multidisciplinary approach to early detection and effective management of this condition in pediatric population.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Ali A. Asadi-Pooya et al.
Summary: The study investigated the prevalence and symptoms of long COVID in children and adolescents in hospitals across Fars province, Iran, from February 19, 2020, to November 20, 2020. A total of 58 patients were included, with 26 (44.8%) experiencing symptoms of long COVID, such as fatigue, shortness of breath, exercise intolerance, weakness, and walking intolerance. Older age, muscle pain on admission, and intensive care unit admission were significantly associated with long COVID.
WORLD JOURNAL OF PEDIATRICS
(2021)
Review
Microbiology
Amy D. Proal et al.
Summary: The novel coronavirus SARS-CoV-2 has led to a pandemic of COVID-19, with some patients developing persistent symptoms known as Long COVID or PASC. These patients may have different underlying biological factors driving their symptoms, such as organ damage, persistent viral reservoirs, re-activation of pathogens, and immune dysregulation. Therapeutic approaches may need to be individualized to effectively manage care for specific patients with PASC.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Infectious Diseases
Shin Jie Yong
Summary: Long COVID or post-COVID-19 syndrome is a poorly understood condition that affects survivors with symptoms like fatigue, dyspnoea, cognitive impairments, and more. The pathophysiology, risk factors, and treatments are still lacking in literature, but potential treatments may include rehabilitation training and repurposed drugs from similar conditions. Further research is needed to substantiate risk factors and treatment options.
INFECTIOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
A. V. Raveendran et al.
Summary: Long COVID refers to the persistence of symptoms in individuals who have recovered from SARS-CoV-2 infection, possibly related to organ damage, post viral syndrome, etc. Clinical evaluation should focus on identifying the pathophysiology and appropriate remedial measures.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Respiratory System
Swapna Mandal et al.
Summary: Following discharge from hospital, a significant number of COVID-19 patients continue to experience persistent symptoms such as breathlessness, cough, fatigue, and depression. Some patients also show elevated levels of biomarkers indicating ongoing health issues. Chest radiographs reveal abnormalities in a considerable portion of patients, with a small percentage showing deterioration.
Article
Medicine, General & Internal
Terence Stephenson et al.
Summary: This study aims to describe the clinical phenotype of Long COVID in children and young people, produce an operational definition, and establish its prevalence in this population. A cohort study will be conducted, analyzing trajectories over time using data visualization techniques and cross-tabulation methods to aid in defining Long COVID.
Review
Immunology
Yu-Han Xing et al.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Microbiology
Maria Luisa Danzetta et al.
Article
Pediatrics
Cecilia L. H. Xu et al.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2020)
Article
Pediatrics
Lael M. Yonker et al.
JOURNAL OF PEDIATRICS
(2020)
Article
Pediatrics
Liene Smane et al.
BMJ PAEDIATRICS OPEN
(2020)
