Overall and patient-specific comparative effectiveness of dimethyl fumarate versus teriflunomide: A novel approach to precision medicine applied to the German NeuroTrans Data Multiple Sclerosis Registry

Article Clinical Neurology

Overall and patient-level comparative effectiveness of dimethyl fumarate and fingolimod: A precision medicine application to the Observatoire Francais de la Sclerose en Plaques registry

Gabrielle Simoneau et al.

Summary: This study compared the real-world effectiveness and discontinuation profiles of dimethyl fumarate and fingolimod as second-line therapies for multiple sclerosis. The results showed similar relapse rates at 12 months, but a lower treatment persistence with dimethyl fumarate. There was no significant treatment effect heterogeneity observed.

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL (2022)

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Article Health Care Sciences & Services

Implementation of a data control framework to ensure confidentiality, integrity, and availability of high-quality real-world data (RWD) in the NeuroTransData (NTD) registry

Knut Wehrle et al.

Summary: A data management and control framework was implemented to support high-quality RWD analysis in disease areas like multiple sclerosis. Regular analysis of random data samples and the establishment of an internal strategy board ensured data accuracy.

JAMIA OPEN (2022)

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Article Mathematical & Computational Biology

A two-stage prediction model for heterogeneous effects of treatments

Konstantina Chalkou et al.

Summary: This study aimed to develop a model estimating the benefit of alternative treatment options for individual patients by combining prognosis research and network meta-analysis methods. The model found that patient characteristics impact treatment effects and can help clinicians choose the best treatment option for patients of different risks.

STATISTICS IN MEDICINE (2021)

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Review Health Care Sciences & Services

Development of Registry Data to Create Interactive Doctor-Patient Platforms for Personalized Patient Care, Taking the Example of the DESTINY System

Arnfin Bergmann et al.

Summary: Real-world evidence is crucial in clinical practice, with data often collected from national and international registries. The DESTINY platform, utilized by the NTD network in Germany, allows for personalized treatment and timely identification of treatment side-effects.

FRONTIERS IN DIGITAL HEALTH (2021)

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Article Clinical Neurology