期刊
NEUROSCIENCE LETTERS
卷 610, 期 -, 页码 171-176出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.09.023
关键词
Rolipram; Cognition; Brain-derived neurotrophic factor; cAMP response element-binding protein; Arc protein
资金
- Chinese National Natural Science Foundation [81300933]
- Shanghai Science and Technology Committee, China [13JC1401504]
Diabetics suffer from a higher risk of cognitive decline, cAMP response element-binding protein (CREB) is a transcription factor associated with memory and synaptic plasticity. Here, we investigated the molecular changes in the hippocampus correlated with diabetes associated cognitive decline (DACD) from a CREB-centered perspective in a rat model of type 2 diabetes. Furthermore, we tested the therapeutic effect of rolipram on DACD. High-fat diet and low-dose streptozocin were adopted to induce diabetes in SD rats. Results show that supplementation with rolipram for 23 days (0.5 mg/kg, once a day) improved the performance of diabetic rats in Morris water navigation task with increased level of CREB, brain-derived neurotrophic factor (BDNF), and Arc protein in the hippocampus. Rolipram, acting as an inhibitor of PDE4, was found to repair the imbalance in the CREB/BDNF/Arc pathway. This study may provide important insights into the mechanisms underlying DACD and provide new therapeutic targets for clinical treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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