期刊
NEUROSCIENCE LETTERS
卷 620, 期 -, 页码 38-42出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.03.041
关键词
Neuropathic pain; Electroacupuncture; GLAST; GLT-1; l-trans-Pyrrolidine-2-4-dicarboxylate
资金
- National Natural Science Foundation of China [31272619]
Glutamate transports (GTs), the only vehicle for removal of glutamate from the extracellular fluid, is reported to be related to chronic pain. To investigate whether the glutamate/aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) participate in electroacupuncture (EA) analgesia, the EA effect was observed with paw withdraw threshold in a rat model of spared nerve injury. The expression levels of GLAST and GLT-1 were determined with Western Blot and RT-PCR. The results showed significantly upregulated GLAST and GLT-1, along with the relieved pain behaviors after EA treatment. In addition, intrathecal injection of GTs inhibitor, L-trans-pyrrolidine-2-4-dicarboxylate, attenuated the EA-induced analgesic effect. The experiment demonstrates that EA can increase the GTs of neuropathic pain rats, which might be one of the mechanisms underlying its effectiveness in the neuropathic pain. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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