4.4 Article

Genetically Engineered Membrane-Coated Nanoparticles as Versatile Platforms with Reduced Protein Corona for Targeted siRNA Delivery

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural-Mesenchymal Transformation in Glioma Stem Cells

Ruiqi Li et al.

Summary: Radiotherapy is a crucial treatment for glioblastoma patients, but recurrence is inevitable. Tumor evolution and the acquisition of radioresistance hinder the efficacy of radiotherapy. Understanding the mechanisms of tumor subclonal evolution can lead to the development of new strategies.

ADVANCED FUNCTIONAL MATERIALS (2023)

Review Chemistry, Multidisciplinary

Mechanistic Understanding of Protein Corona Formation around Nanoparticles: Old Puzzles and New Insights

Karin Nienhaus et al.

Summary: Although a variety of nanoparticles have been developed for medical use, their application in clinical settings is limited. The lack of understanding of nanoparticle interactions in the bio-environment, particularly the protein corona, is a major obstacle. This article critically reviews research on the protein corona, including its structure, reversibility, time dependence, and role in nanoparticle agglomeration, highlighting the need for further mechanistic studies. The article concludes with a discussion of future research directions to enhance the understanding of the protein corona and improve the design of nanomedicines.
Article Nanoscience & Nanotechnology

Surgically Derived Cancer Cell Membrane-Coated R837-Loaded Poly(2-Oxazoline) Nanoparticles for Prostate Cancer Immunotherapy

Shengxian Li et al.

Summary: To improve the efficiency of cancer vaccines, personalized cancer vaccines and effective delivery systems are required. In this study, personalized cancer cell membranes (CCMs) were prepared from surgically harvested cancer tissues and used as tumor-associated antigens (TAAs). The personalized CCMs were then coated onto nanoparticles loaded with imiquimod (R837) to efficiently deliver them to draining lymph nodes and elicit enhanced antitumor immune responses. When combined with programmed cell death-1 antibodies, the coated nanoparticles exhibited high efficiency against tumor progression. Therefore, personalized CCM-coated nanoparticles represent a promising cancer vaccine with significant potential for cancer immunotherapy.

ACS APPLIED MATERIALS & INTERFACES (2023)

Article Chemistry, Multidisciplinary

Tumor-Antigen Activated Dendritic Cell Membrane-Coated Biomimetic Nanoparticles with Orchestrating Immune Responses Promote Therapeutic Efficacy against Glioma

Xiaoyue Ma et al.

Summary: This study developed an activated mature dendritic cell membrane-coated nanoplatform, aDCM@PLGA/RAPA, which can cross the blood-brain barrier and improve the immune micro-environment, effectively inhibiting glioma growth with great potential for antiglioma immunotherapy.

ACS NANO (2023)

Article Engineering, Environmental

Activated T cell-derived exosomes for targeted delivery of AXL-siRNA loaded paclitaxel-poly-L-lysine prodrug to overcome drug resistance in triple-negative breast cancer

Chuanrong Chen et al.

Summary: Triple-negative breast cancer (TNBC) lacks effective treatment options due to tumor heterogeneity and immunosuppressive microenvironment. This study developed a novel platform, PP/siAXL@EXO, to overcome these obstacles. It involves AXL-siRNA loaded PTX-PLL prodrug micelle encapsulated within activated T cell-derived exosome delivery system. This platform effectively inhibits PTX-resistant tumor growth and metastasis, induces protective immune memory, and provides a potential therapeutic strategy for TNBC.

CHEMICAL ENGINEERING JOURNAL (2023)

Review Oncology

Insight into lipid-based nanoplatform-mediated drug and gene delivery in neuro-oncology and their clinical prospects

Manasa Manjunath Hegde et al.

Summary: Tumors of the CNS range from benign to highly malignant and aggressive lesions. Conventional treatments lack specificity, highlighting the need for precise therapeutic strategies. Lipid-based nanoparticulate systems have a breakthrough impact on CNS tumor management, particularly in brain targeting, imaging, and drug/gene delivery with immunotherapy. These platforms improve antitumor activity and selectively target brain tumors.

FRONTIERS IN ONCOLOGY (2023)

Review Oncology

mRNA-based cancer therapeutics

Chuang Liu et al.

Summary: Due to its advantages in terms of production speed and cost reduction, mRNA technology has been widely used in the development of diverse vaccines and treatments. mRNA-based therapeutics have shown promising efficacy in preclinical studies and some have entered clinical trials. With the support from evidence of effectiveness and safety of clinically approved mRNA vaccines, along with increasing interest, mRNA technology is expected to become a major pillar in cancer drug development. This review provides an overview of in vitro transcribed mRNA-based therapeutics for cancer treatment, including characteristics, delivery systems, preclinical and clinical studies, current challenges, and future prospects in the field. The translation of promising mRNA-based treatments into clinical applications is anticipated to benefit patients.

NATURE REVIEWS CANCER (2023)

Article Chemistry, Analytical

Cell membrane-coated biomimetic magnetic nanoparticles for the bio-specific extraction of components from Gualou Guizhi decoction exhibiting activities against oxygen-glucose deprivation/reperfusion injury

Dongmei He et al.

Summary: The study successfully identified six bioactive compounds from Gua-Lou-Gui-Zhi decoction using a cell membrane-coated magnetic bead binding experiment, which were found to protect brain endothelial cells against oxygen-glucose deprivation/reperfusion injury.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

Article Biotechnology & Applied Microbiology

Peptide-based semiconducting polymer nanoparticles for osteosarcoma-targeted NIR-II fluorescence/NIR-I photoacoustic dual-model imaging and photothermal/photodynamic therapies

Ying Yuan et al.

Summary: This study developed semiconductor polymer nanoparticles for targeted photothermal therapy and photodynamic therapy in osteosarcoma. The nanoparticles showed efficient cellular uptake and enhanced therapeutic effects, leading to significant anti-tumor activities both in vitro and in vivo.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Biotechnology & Applied Microbiology

Functional nanovesicles displaying anti-PD-L1 antibodies for programmed photoimmunotherapy

Hu Chen et al.

Summary: This study demonstrates a promising strategy for ligand-targeted and personalized cancer photoimmunotherapy by using bone marrow mesenchymal stem cell-derived nanovesicles for targeted drug delivery and photothermal ablation. The selective delivery of photosensitizers and antigen-antibody integrators to tumor tissues significantly improves the efficacy of immunotherapy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Review Biochemistry & Molecular Biology

The landscape of mRNA nanomedicine

Xiangang Huang et al.

Summary: mRNA is an emerging therapeutic agent with great potential for revolutionizing life science and medical research. Recent progress in mRNA engineering and delivery has addressed the challenges related to stability, immunogenicity, and in vivo delivery. The success of mRNA vaccines against COVID-19 has transformed the field and opened up possibilities for treating other diseases.

NATURE MEDICINE (2022)

Article Chemistry, Multidisciplinary

Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion

Nima Aliakbarinodehi et al.

Summary: This study investigates the pH dependency of the binding kinetics of ionizable lipid-containing LNPs to an endosomal model membrane. The formation of protein corona on LNPs affects the interaction between LNPs and endosomal membranes. Lipoprotein-depleted serum increases mRNA-controlled protein production.

ACS NANO (2022)

Review Nanoscience & Nanotechnology

Opportunities and challenges for the clinical translation of structuredDNAassemblies as gene therapeutic delivery and vaccine vectors

Marina A. Dobrovoskaia et al.

Summary: Gene therapeutics show promise in treating genetic diseases and cancer through modulation of gene expression and immune cell activation, but face limitations in toxicity, targeting, and efficiency compared to viral vectors. Structured DNA assemblies fabricated using DNA origami principles offer a new nonviral delivery vector with controllable immunostimulatory properties and low manufacturing cost.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2021)

Article Oncology

DDAB cationic lipid-mPEG, PCL copolymer hybrid nano-carrier synthesis and application for delivery of siRNA targeting IGF-1R into breast cancer cells

M. Khodaei et al.

Summary: Using new lipid-polymer hybrid nanoparticles as a carrier for siRNA, efficient silencing of IGF-1R gene overexpression in MCF-7 human breast cancer cell line was achieved. The complex showed optimal efficiency at N/P ratio of 40 with a high siRNA encapsulation rate of 95%. It demonstrated superior down-regulation of the target gene compared to controls.

CLINICAL & TRANSLATIONAL ONCOLOGY (2021)

Article Cell Biology

The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior

Yufeng Jia et al.

Summary: Promoting BDNF expression is beneficial for depression treatment. Recent research has identified Pdcd4 as a novel target for antidepressant therapy. Delivery of RVG/siPdcd4 complex can upregulate BDNF levels and downregulate neuroinflammatory cytokine expression, offering potential as a therapeutic medicine for depression.

CELL DEATH & DISEASE (2021)

Article Biochemistry & Molecular Biology

Isolation and Characterization of Buccal Fat Pad and Dental Pulp MSCs from the Same Donor

Tullio Genova et al.

Summary: Mesenchymal stem cells (MSCs) from third molar dental pulp and buccal fat pads of patients were compared for osteoinductive potential. The study found higher yield and proliferation of cells in BFPSCs compared to DPSCs, although both could differentiate into osteoblast-like cells and release a mineralized matrix. The release of osteocalcin did not significantly differ between the two types of stem cells.

BIOMEDICINES (2021)

Article Multidisciplinary Sciences

Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs

Joon Ho Park et al.

Summary: By exploiting the specific affinity between VLA-4 and VCAM-1, a biomimetic nanoparticle formulation capable of targeting inflammation sites was developed. These nanoparticles coated with cell membranes showed enhanced affinity to target cells, improving the delivery of anti-inflammatory drugs to inflamed lungs and demonstrating significant therapeutic efficacy in vivo.

SCIENCE ADVANCES (2021)

Article Biotechnology & Applied Microbiology

Safety considerations for nanoparticle gene delivery in pediatric brain tumors

Kathryn M. Luly et al.

NANOMEDICINE (2020)

Article Chemistry, Multidisciplinary

In vivo formation of protein corona on gold nanoparticles. The effect of their size and shape

Rafaela Garcia-Alvarez et al.

NANOSCALE (2018)

Article Chemistry, Multidisciplinary

Genetically Engineered Liposome-like Nanovesicles as Active Targeted Transport Platform

Pengfei Zhang et al.

ADVANCED MATERIALS (2018)

Article Nanoscience & Nanotechnology

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

Tyrel T. Smith et al.

NATURE NANOTECHNOLOGY (2017)

Article Chemistry, Multidisciplinary

Targeted Delivery of CRISPR/Cas9-Mediated Cancer Gene Therapy via Liposome-Templated Hydrogel Nanoparticles

Zeming Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Review Cardiac & Cardiovascular Systems

Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation

Melvin Y. Rincon et al.

CARDIOVASCULAR RESEARCH (2015)

Article Biochemistry & Molecular Biology

Safety and angiogenic effects of systemic gene delivery of a modified erythropoietin

A. M. de Lucas Cerrillo et al.

GENE THERAPY (2015)

Review Biotechnology & Applied Microbiology

Ligand-targeted liposome design: challenges and fundamental considerations

Gavin T. Noble et al.

TRENDS IN BIOTECHNOLOGY (2014)

Editorial Material Pharmacology & Pharmacy

The Role of Gene- and Drug Delivery in women's health - Unmet clinical needs and future opportunities Preface

Margit M. Janat-Amsbury et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)