☆ 4.4 Review

Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

ADVANCED THERAPEUTICS (2023)

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Review Chemistry, Multidisciplinary

Prospects for hypoxia-based drug delivery platforms for the elimination of advanced metastatic tumors: From 3D modeling to clinical concepts

Mohammad Shahpouri et al.

Summary: Hypoxia in solid tumors contributes to drug resistance, metastasis, and cancer relapse, but also provides an opportunity for targeting hypoxic tumor regions. This study discusses various strategies for dealing with hypoxia in deep-seated tumor cells, including their combination with other approaches like photodynamic therapy. The potential and limitations of these approaches, as well as current 3D hypoxia modeling systems, are also examined. Additionally, the potential and current status of preclinical tumor hypoxia approaches in clinical trials for advanced cancer are discussed.

JOURNAL OF CONTROLLED RELEASE (2023)

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Article Chemistry, Physical

Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

Lan Yang et al.

Summary: The study developed a multifunctional nanoparticle that can release CO and generate ROS in the tumor microenvironment, demonstrating desirable anticancer effect and therapeutic safety.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2023)

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Article Nanoscience & Nanotechnology

A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion

Seung Mo Jin et al.

Summary: In this study, a kinetically activating nanoadjuvant (K-nanoadjuvant) is proposed to integrate two waves of innate immune stimuli, resulting in effective antitumour immunity without immune cell exhaustion. The combinatorial code of K-nanoadjuvant is optimized in terms of the order, duration, and time window between activating Toll-like receptor 7/8 agonist and other Toll-like receptor agonists. K-nanoadjuvant induces effector/non-exhausted dendritic cells, CD8(+) T cells, and natural killer cells, leading to strong antitumour immunity with minimal toxicity when used as a monotherapy or in combination therapy with other treatments.

NATURE NANOTECHNOLOGY (2023)

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Article Acoustics

A hybrid nanoassembly for ultrasound-inducible cytosolic siRNA delivery and cancer sono-gene therapy

Gaigai Li et al.

Summary: This study developed a sono-controllable strategy for effective cytoplasmic delivery of siRNAs in cancer gene therapy. A hybrid nano-assembly (HNA) was prepared, which generated singlet oxygen to facilitate the escape of siRNA from the lysosome to the cytoplasm. The combination of sono-gene therapy achieved a high cell death rate of 82%.

ULTRASONICS SONOCHEMISTRY (2023)

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Review Pharmacology & Pharmacy

Improving solubility of poorly water-soluble drugs by protein-based strategy: A review

Xiaowen Liu et al.

Summary: Poorly water-soluble drugs pose a significant challenge in pharmaceutical development due to their low solubility, which can result in reduced bioavailability and therapeutic effectiveness. Efforts have been made to improve the solubility of these drugs for better pharmacokinetics and pharmacodynamics. Protein-based strategies, which offer natural advantages such as versatile interactions with hydrophobic drugs, biocompatibility, biodegradation, and protein metabolism, have gained special interest. This review summarizes the advancements in using proteins, including plant proteins, mammalian proteins, and recombinant proteins, to enhance the water solubility of poorly water-soluble drugs.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Multidisciplinary Sciences

Photoactivatable nanoagonists chemically programmed for pharmacokinetic tuning and in situ cancer vaccination

Jianqin Wan et al.

Summary: A photoactivatable toll-like receptor 7/8 (TLR7/8) nanoagonist system is developed to induce near-infrared light-induced immunogenic cell death (ICD) in dying tumor cells and release a potent immunoadjuvant. In mouse models, this system effectively eliminates tumors, suppresses tumor recurrence and metastasis, and activates tumor-specific T cells. This study provides a simple and cost-effective approach to generate in situ cancer vaccines for the photodynamic immunotherapy of metastatic cancers.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

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Article Chemistry, Multidisciplinary

Hsp70-Targeting and Size-Tunable Nanoparticles Combine with PD-1 Checkpoint Blockade to Treat Glioma

Rou Xie et al.

Summary: To enhance drug delivery to glioma, researchers proposed Hsp70-targeting and acid-triggered self-assembled gold nanoparticles (D-A-DA/TPP) for selective delivery of doxorubicin (DOX) to glioma. The results showed that D-A-DA/TPP can induce more glioma apoptosis and combination with PD-1 checkpoint blockade significantly improved median survival time. This study offers a potential nanocarrier combining size-tunable strategy with active targeting ability to increase drug enrichment in glioma and synergizes with PD-1 checkpoint blockade to achieve chemo-immunotherapy.

SMALL (2023)

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Article Chemistry, Multidisciplinary

Tumor-Microenvironment-Activatable Polymer Nano-Immunomodulator for Precision Cancer Photoimmunotherapy

Jing Liu et al.

Summary: This study reports a smart semiconducting polymer nano-immunomodulator that can achieve precise regulation of photodynamic immunotherapy for cancer in the acidic tumor microenvironment. The release of immunogenic factors and TLR7 agonist at the tumor site activates dendritic cells, leading to strong antitumor activities. Additionally, the nano-immunomodulator can directly eradicate tumors and induce immunogenic cancer cell death. This approach enhances systemic antitumor immune responses, resulting in inhibition of tumor growth and metastasis.

ADVANCED MATERIALS (2022)

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Article Pharmacology & Pharmacy

A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy

Yihan Wu et al.

Summary: In this study, a pH-sensitive supramolecular nanosystem was designed for co-delivery of Ce6 and TPL, exhibiting ideal drug release characteristics and enhanced cellular uptake capacity. TPL+Ce6/NPs showed significant synergistic chemo-photodynamic therapeutic effects in vitro and in vivo, with lower systemic toxicity in tumor-bearing mice.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy

Sheng-Jyun Huang et al.

Summary: In this study, acidity-responsive nanovehicles were developed for efficient intracellular drug release. The nanovehicles exhibited excellent colloidal stability and accelerated drug release, leading to enhanced anticancer efficacy in vitro and in vivo.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Engineering, Biomedical

Noninvasive remote-controlled nanomedicine by using electric field stimulation for in vivo effective cancer therapy

Ziang Liu et al.

Summary: Precision therapy has become an important strategy for cancer treatment. In this study, an external electric field controlled targeting drug delivery nanosystem was developed for precision cancer therapy. The nanosystem showed high electric field response and significantly increased tumor inhibition rate in experimental models. It demonstrated biodegradability, biocompatibility, and the ability to remotely control electric fields, making it a promising nanomedicine platform for potential clinical applications of electrodynamic therapy.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

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Article Engineering, Biomedical

Injectable in situ intelligent thermo-responsive hydrogel with glycyrrhetinic acid-conjugated nano graphene oxide for chemo-photothermal therapy of malignant hepatocellular tumor

Huahua Wang et al.

Summary: This study prepared an in-situ thermo-sensitive hydrogel of berberine hydrochloride (BH) based on glycyrrhetinic acid (GA) modified nano graphene oxide (NGO). The physicochemical properties and anti-tumor activity of the hydrogel were investigated. The results showed sustained and temperature-dependent drug release from the hydrogel, and enhanced tumor targeting. Additionally, the hydrogel exhibited enhanced inhibitory effect when combined with laser irradiation.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

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Article Chemistry, Applied

A dual drug delivery platform based on thermo-responsive polymeric micelle capped mesoporous silica nanoparticles for cancer therapy

Hongyu Long et al.

Summary: The combination of organic polymers and inorganic nanoparticles to design intelligent nanocarriers is important for delivering anticancer drugs to tumor cells effectively. In this study, a thermo-responsive micelle was prepared as a gatekeeper attached to the surface of mesoporous silica nanoparticle through disulfide bonds. The dual drug delivery platform showed controllable release of drugs and demonstrated high cytocompatibility and cytotoxicity against cancer cells.

MICROPOROUS AND MESOPOROUS MATERIALS (2022)

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Article Pharmacology & Pharmacy

Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer

Wenfeng Jia et al.

Summary: In this study, a dual-response shape transformation and charge reversal strategy was designed to improve the anti-tumor effect using chemo-photodynamic therapy. The tumor microenvironment-responsive nanoparticles were constructed to achieve charge reversal, size reduction, and enhanced tumor penetration, and induce tumor cell death by releasing chemotherapy drugs through the photosensitizer.

ACTA PHARMACEUTICA SINICA B (2022)

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Review Oncology

The Role of Photodynamic Therapy in Triggering Cell Death and Facilitating Antitumor Immunology

Liuchang Tan et al.

Summary: This paper reviews the tumor treatment strategies of photodynamic therapy (PDT) combined with anti-tumor immunotherapy, focusing on the stimulating effect of PDT on tumor immune response and the mechanisms of enhancing efficacy.

FRONTIERS IN ONCOLOGY (2022)

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Article Chemistry, Multidisciplinary

Metal-phenolic networks with ferroptosis to deliver NIR-responsive CO for synergistic therapy

Jiamei Li et al.

Summary: In this study, a thermosensitive boronic acid group-containing CO prodrug was synthesized and fabricated with tannic acid and iron to form metal-phenolic networks. The prodrug has the ability of tumor-targeting delivery and can be combined with photothermal therapy for synergistic treatment, while enhancing ferroptosis. Combined with CTLA-4 blockade immunotherapy, the prodrug significantly inhibited breast tumor growth, suppressed lung metastasis and improved antitumor immune response.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Applied

Dual-pH responsive chitosan nanoparticles for improving in vivo drugs delivery and chemoresistance in breast cancer

Qiang Chen et al.

Summary: Efficient dual-pH responsive chitosan nanoparticles were fabricated to treat MDR tumors, showing high toxicity and strong antitumor efficiency in vivo.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Multidisciplinary

Platinum-Coordinated Dual-Responsive Nanogels for Universal Drug Delivery and Combination Cancer Therapy

Qiu-Yi Duan et al.

Summary: A dual-responsive nanogel platform is constructed in this study, which possesses excellent drug loading and intracellular delivery capabilities. The nanogel can degrade and release drugs when encountering hyaluronidase or glutathione, and it can also deliver proteins without hinderance from serum proteins and maintain enzymatic activities. Furthermore, the nanogel can co-deliver different cargoes for combination therapy.

SMALL (2022)

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Article Pharmacology & Pharmacy

Dual-Responsive multifunctional ?core-shell? magnetic nanoparticles promoting Fenton reaction for tumor ferroptosis therapy

Hao Chi et al.

Summary: In this study, acid and redox dual-responsive multifunctional magnetic nanoparticles were developed for tumor ferroptosis therapy. The nanoparticles showed magnetic targeting and active targeting properties, and were able to induce cell death in tumor cells.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Chemistry, Multidisciplinary

A Fe(III)-porphyrin-oxaliplatin(IV) nanoplatform for enhanced ferroptosis and combined therapy

Xiaochun Hu et al.

Summary: This study successfully developed a nanotheranostics that promotes the synergistic effect of chemotherapy/ferroptosis/immunomodulation in cancer. The nanotheranostics utilize the characteristics of drug prodrug and metal-organic frameworks to achieve controllable chemotherapy and ferroptosis in the tumor microenvironment.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Preparation and application of pH-responsive drug delivery systems

Haitao Ding et al.

Summary: Microenvironment-responsive drug delivery systems (DDSs) achieve targeted drug delivery and improve drug efficacy by responding to specific pH conditions in diseased tissues. Various synthetic approaches have been developed to prepare pH-sensitive DDSs, including the introduction of pH-sensitive chemical bonds or groups. Different nano DDSs, such as liposomes, micelles, hydrogels, dendritic macromolecules, and organic-inorganic hybrid nanoparticles, can respond to pH variations. These pH-sensitive DDSs have been applied in research on anticancer therapy and the diagnosis of cancer, inflammation, antibacterial infection, and neurological diseases.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Taxanes prodrug-based nanomedicines for cancer therapy

Linlin Sun et al.

Summary: Malignant tumors pose a great threat to human health, and chemotherapy using taxanes is an important treatment option. However, the hydrophobicity, off-target toxicity, and multidrug resistance of taxanes restrict their therapeutic effects. Prodrug-based nanomedicines (PNS) have shown great potential in cancer therapy due to their advantages such as high drug loading efficiency, low immunogenicity, tumor stimuli-responsive drug release, and combinational therapy. This review summarizes the latest developments in taxanes prodrugs-based nanomedicines (TPNS), including polymer-drug conjugate-based nanoformulations, small molecular prodrug-based self-assembled nanoparticles, and prodrug-encapsulated nanosystems. The future challenges of TPNS for clinical translation are also discussed.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Biotechnology & Applied Microbiology

Thermo- and Light-Responsive Polymer-Coated Magnetic Nanoparticles as Potential Drug Carriers

Guihua Cui et al.

Summary: A series of thermo- and light-responsive copolymers were synthesized and successfully modified on the surface of iron oxide nanoparticles. The resulting nanoparticles exhibited excellent thermo-sensitivity and photo-sensitivity, and showed no significant cytotoxicity in cell viability assays, indicating potential for drug delivery in tumor microenvironment.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma

Daniela N. Cespedes-Valenzuela et al.

Summary: This study aims to develop a stimuli-responsive hydrogel that eliminates microtumor residues from melanoma through the coupled effect of photothermal therapy and drug release. Additionally, an in silico model was developed to optimize the treatment process and evaluate its efficacy on melanoma cell cultures.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges

Francisco Rodriguez et al.

Summary: This review provides an overview of nanomedicine for cancer treatment, focusing on the rationale behind their designs and applications. It highlights the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. The perspectives and challenges for nanopharmaceuticals in this field are also discussed.

BIOMOLECULES (2022)

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Review Chemistry, Multidisciplinary

Emerging Strategies in Stimuli-Responsive Prodrug Nanosystems for Cancer Therapy

Chendi Ding et al.

Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.

ACS NANO (2022)

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Article Engineering, Biomedical

ROS-cleavable diselenide nanomedicine for NIR-controlled drug release and on-demand synergistic chemo-photodynamic therapy

Ren Zhu et al.

Summary: Many chemotherapeutic drugs and photosensitizers face challenges such as poor solubility, unspecific delivery, and uncontrollable release, which limit their biomedical applications. In this study, a novel type of ROS-cleavable hydrophilic diselenide nanoparticles was designed to overcome these limitations, allowing for precise and controlled release of the hydrophobic drug and photosensitizer. The NIR-controlled release of the drugs led to on-demand synergistic chemo-/photodynamic therapeutic effects, maximizing tumor growth suppression and minimizing side effects.

ACTA BIOMATERIALIA (2022)

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Article Biochemistry & Molecular Biology

Hydrogen Bond-Mediated Supramolecular Polymeric Nanomedicine with pH/Light-Responsive Methotrexate Release and Synergistic Chemo-/Photothermal Therapy

Yanggui Wu et al.

Summary: The article introduces the construction of supramolecular polymer micelles using H-bond technology, loaded with chemotherapeutic drugs and photothermal agents for synergistic chemo-/photothermal therapies. These nanomedicines have enhanced drug loading capacity, transport performance, and stimuli-responsive drug release.

BIOMACROMOLECULES (2022)

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Review Pharmacology & Pharmacy

Recent Strategies to Address Hypoxic Tumor Environments in Photodynamic Therapy

Yuyin Du et al.

Summary: Photodynamic therapy (PDT) is a promising cancer treatment method due to its noninvasiveness and low toxicity. However, the effectiveness of PDT is significantly reduced in hypoxic tumor environments. Researchers are exploring strategies such as oxygen transport, oxygen generation, reducing oxygen consumption, and regulating tumor microenvironments to overcome tumor hypoxia and enhance PDT.

PHARMACEUTICS (2022)

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Article Medicine, General & Internal

Institutional Surgical Response and Associated Volume Trends Throughout the COVID-19 Pandemic and Postvaccination Recovery Period

Soham Ghoshal et al.

Summary: This study investigates the impact of the COVID-19 pandemic on surgical procedure volumes. The study found that during the peak of the pandemic, surgical volumes declined by 44.6%, and after the peak, volumes only recovered to 85.8% of pre-COVID levels. The recovery rates varied across subspecialties and case classes.

JAMA NETWORK OPEN (2022)

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Review Materials Science, Biomaterials

Connecting the dynamics and reactivity of arylboronic acids to emergent and stimuli-responsive material properties

Gun Su Han et al.

Summary: Over the past two decades, arylboronic acid-functionalized materials have been widely used in sensing and stimuli-responsive applications. The unique reactivity of arylboronic acids allows for self-healing properties in crosslinked hydrogels, degradation in acidic environments and presence of diols, and oxidation in the presence of reactive oxygen species. Understanding the chemistry of arylboronic acids can improve the design of stimuli-responsive materials.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Engineering, Biomedical

Development ofROS-responsive amino acid-based poly(ester amide) nanoparticle for anticancer drug delivery

Qinghua Xu et al.

Summary: Reactive oxygen species play a critical role in cellular metabolism and the pathogenesis of various diseases, making biomaterials responsive to ROS levels important in biomedical applications. The ROS-responsive polymer Met-PEA-PEG nanoparticle showed promising results in delivering anticancer drugs and enhancing their therapeutic effects.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Review Oncology

The Smart Dual-Stimuli Responsive Nanoparticles for Controlled Anti-Tumor Drug Release and Cancer Therapy

Feng Wu et al.

Summary: Stimuli-responsive nanoparticles have emerged as a smart and effective targeted delivery platform for drug transportation, with dual-stimuli responsive nanoparticles showing excellent control over drug delivery and release, particularly in cancer treatment. These nanoparticles can improve encapsulation and delivery efficiency of chemotherapy drugs, combine different therapies, apply imaging functions, and overcome Multi-Drug Resistance (MDR).

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

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Article Pharmacology & Pharmacy

Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment

Xiaojie Chen et al.

Summary: In this study, nanoparticles with dual-responsive, tumor targeting characteristics were designed for the treatment of breast cancer through the combination of photothermal therapy and chemotherapy. The variability in nanoparticle size and characteristics enhanced drug release and therapeutic efficacy against breast cancer.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Chemistry, Multidisciplinary

Metformin Mediated PD-L1 Downregulation in Combination with Photodynamic-Immunotherapy for Treatment of Breast Cancer

Chuan Hu et al.

Summary: The study introduces a novel self-delivery nanoparticle system for immunotherapy with unique design features. These nanoparticles exhibit drug release and strong anti-tumor immune effects in the tumor microenvironment, leading to significant improvements in therapeutic outcomes.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Biomedical

Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors

Jingke Fu et al.

Summary: Hypoxia is closely related to drug resistance in solid tumors. A developed nanomedicine can sensitize apoptosis and ferroptosis, effectively inhibiting tumor growth by overcoming hypoxia-induced resistance to chemotherapy.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Hypoxia-Triggered Self-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging Signal of a Tumor

Huige Zhou et al.

Summary: Hypoxia is common in solid tumors and affects tumor response to therapy. Understanding tumor hypoxia distribution is crucial for personalized treatment. A novel hypoxia imaging probe provides dual-mode imaging in vivo, enhancing detection of hypoxic regions in solid tumors.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Multidisciplinary

Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer

Fang Sun et al.

Summary: The study presents a novel strategy to enhance photoimmunotherapy of pancreatic cancer by provoking T cells activation and overcoming adaptive immune resistance.

ADVANCED SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Current Limitations and Recent Progress in Nanomedicine for Clinically Available Photodynamic Therapy

Jooho Park et al.

Summary: Photodynamic therapy (PDT) using oxygen, light, and photosensitizers is a promising approach for cancer treatment. Current progress involves enhancing accumulation of photosensitizers in tumor sites using nanocarriers and future research directions include improving drug localization and optimizing treatment outcomes.

BIOMEDICINES (2021)

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Article Engineering, Biomedical

Tuning the efficacy of esterase-activatable prodrug nanoparticles for the treatment of colorectal malignancies

Yuchen Wang et al.

Summary: A novel nanoparticle drug delivery system targeting colorectal cancer was developed in this study, which significantly improved the efficacy of the drug compared to current standard treatments. The nanoparticles increased the intratumoral concentration of the therapeutic agent, leading to reduced side effects during treatment.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy

Zhouqi Meng et al.

Summary: This study presents an ultrasound-responsive self-healing hydrogel system for controlled tumor vaccine release and personalized cancer immunotherapy. Through multiple ultrasound treatments, nanovaccines could be repeatedly released from the gel to elicit antitumor immune responses, effectively inhibiting established tumors and preventing postoperative tumor metastases and recurrence.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer

Fengqi Zhou et al.

Summary: The study introduces a sequential prodrug nanovesicle designed to enhance drug delivery to tumor tissues and reduce immunological resistance of tumor cells. The nanovesicles show promising results in inhibiting tumor growth and suppressing metastasis in mouse models, providing a new approach for chemoimmunotherapy of cancers by overcoming immune evasion through the IFN-gamma-BRD4-PD-L1 axis.

NANO TODAY (2021)

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Article Engineering, Biomedical

CO/chemosensitization/antiangiogenesis synergistic therapy with H2O2-responsive diselenide-containing polymer

Jichun Yang et al.

Summary: This study developed H2O2-responsive diselenide-containing micelles that combine CO therapy with chemosensitization therapy and AAT. The micelles released CO and GEM in response to intratumoral H2O2, reducing side effects and enhancing chemotherapeutic effects. The oxidation of diselenide bonds in the micelles suppressed the expression of VEGF and MMP-2, achieving AAT.

BIOMATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Near-infrared light-triggered nano-prodrug for cancer gas therapy

Runcong Liu et al.

Summary: Gas therapy as a new cancer treatment method has gained increasing attention in recent years. By using near-infrared light as a stimulus to trigger the release of gas molecules, it has achieved improved therapeutic efficacy and reduced side effects.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

An overview and bibliometric analysis on the colorectal cancer therapy by magnetic functionalized nanoparticles for the responsive and targeted drug delivery

Mahdieh Darroudi et al.

Summary: Nanomedicine is a rapidly growing scientific field that applies nanomaterials for therapeutic and diagnostic purposes, with a focus on magnetic nanoparticles for drug delivery in cancer treatment. These nanoparticles show promise as responsive carriers with specific triggers, along with biocompatibility, chemical stability, and the ability to localize to tumor sites with the help of external magnetic fields.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Microenvironment-Responsive Prodrug-Induced Pyroptosis Boosts Cancer Immunotherapy

Yao Xiao et al.

Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.

ADVANCED SCIENCE (2021)

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Article Biotechnology & Applied Microbiology

A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution

Sen Liu et al.

Summary: This study introduced a dual-responsive nano-carrier that can rapidly release drugs in the tumor microenvironment, increasing the effective drug concentration in the tumor. Experimental results demonstrated that the dual-responsive nano-carrier exhibited more efficient anti-tumor effects compared to single-responsive nano-carriers.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Materials Science, Biomaterials

Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy

Liuhui Zhang et al.

Summary: This study proposed a unique ROS and GSH dual responsive nanocarrier (PCL-SS) for DTX delivery to improve the efficacy of chemotherapy for prostate cancer. The nanocarrier was found to enhance drug accumulation at tumor sites and minimize systemic side effects.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Analytical

Nanoplatform based on GSH-responsive mesoporous silica nanoparticles for cancer therapy and mitochondrial targeted imaging

Hang He et al.

Summary: The study developed a mitochondrial-targeted drug delivery system which can release drugs in a GSH-dependent manner and achieve near-infrared fluorescence imaging of mitochondria. This system shows promising activity in anti-tumor therapy.

MICROCHIMICA ACTA (2021)

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Article Nanoscience & Nanotechnology

Laser/GSH-Activatable Oxaliplatin/Phthalocyanine-Based Coordination Polymer Nanoparticles Combining Chemophotodynamic Therapy to Improve Cancer Immunotherapy

Ziyuan Huang et al.

Summary: The study introduces a laser/glutathione-activatable nanosystem for highly efficient immunotherapy by promoting tumor penetration and uptake. This nanosystem containing oxaliplatin, phthalocyanine, and IDO1 inhibitor triggers ROS production at the tumor site, leading to drug release, inhibition of tumor growth, and induction of immunogenic cell death. The research suggests that in deep tumors, this laser/glutathione-activatable drug delivery system can enhance immunogenic cell death and reverse immune suppression physiopathology.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Bioinspired Microenvironment Responsive Nanoprodrug as an Efficient Hydrophobic Drug Self-Delivery System for Cancer Therapy

Pengping Xu et al.

Summary: A bioinspired coordination-driven self-assembly strategy was developed to manufacture artemisinin-based nanoprodrug, which showed high drug loading efficiency and low preparation complexity. The nanoprodrug demonstrated favorable characteristics for cancer targeting in vivo.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Visible-Light-Triggered Prodrug Nanoparticles Combine Chemotherapy and Photodynamic Therapy to Potentiate Checkpoint Blockade Cancer Immunotherapy

Jiwoong Choi et al.

Summary: Immune checkpoint blockade is a promising approach for cancer immunotherapy, but many patients do not respond due to the immunosuppressive tumor microenvironment. This study proposes visible-light-triggered prodrug nanoparticles (LT-NPs) to reverse the immunosuppressive tumor microenvironment and enhance checkpoint blockade immunotherapy, showing promising results in tumor models.

ACS NANO (2021)

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Review Medicine, Research & Experimental

Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

Pushkar Singh Rawat et al.

Summary: Doxorubicin, a commonly used anti-cancer drug, exerts its activity through DNA intercalation and inhibition of topoisomerase II enzyme. However, its use is limited by its dose-dependent cardiotoxicity, which is believed to involve oxidative stress, apoptosis, and various other mechanisms. Pharmacological strategies have been explored to mitigate Doxorubicin-induced cardiotoxicity.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

ATP and cancer immunosurveillance

Oliver Kepp et al.

Summary: In the TME, intracellular ATP plays a critical role in bioenergetic metabolism, while extracellular ATP functions as a signal transducer, affecting biology dependent on receptor types, cell types, and regulatory circuitry activation status. Additionally, extracellular ATP is rapidly degraded, leading to the accumulation of metabolites with distinct biological effects.

EMBO JOURNAL (2021)

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Article Pharmacology & Pharmacy

A small molecule nanodrug consisting of pH-sensitive ortho ester-dasatinib conjugate for cancer therapy

Jialu Gao et al.

Summary: The study developed a self-delivered prodrug system with nanoscale characteristics to enhance tumor therapy efficacy. The pH-sensitive prodrug nanoparticles simultaneously released dasatinib and doxorubicin, demonstrating remarkable antitumor effects. This prodrug system shows great potential in cancer therapy.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

Thermo-responsive hydrogels for cancer local therapy: Challenges and state-of-art

Diana Rafael et al.

Summary: Despite extensive efforts from the scientific community, advanced cancer remains incurable. However, thermo-responsive hydrogels have shown promise in improving the efficacy of anticancer drugs and reducing adverse effects, leading to advancements in cancer treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

GSH-Responsive Nanoprodrug to Inhibit Glycolysis and Alleviate Immunosuppression for Cancer Therapy

Xiaohan Liu et al.

Summary: The study synthesized a nanoprodrug that can inhibit glycolysis of cancer cells and alleviate the immunosuppressive microenvironment by releasing two drugs, which increased intracellular oxidative stress and induced immunogenic cell death of cancer cells. This strategy opens up new possibilities for exploring dimeric prodrugs for synergistic cancer therapy.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Switching on prodrugs using radiotherapy

Jin Geng et al.

Summary: The article introduces a chemistry-based strategy for simultaneous chemo-radiotherapy by activating cancer prodrugs through irradiation, enabling site-directed chemotherapy instead of systemic chemotherapy, which opens up a new era in targeted and directed chemotherapy.

NATURE CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Photoresponsive PAMAM-Assembled Nanocarrier Loaded with Autophagy Inhibitor for Synergistic Cancer Therapy

Manman Jing et al.

Summary: The study presents a photoresponsive PAMAM-assembled nanoparticle loaded with an autophagy inhibitor, which can precisely control drug release and achieve significant antitumor effects in vitro and in vivo. By combining the anticancer properties of PAMAM and the autophagy inhibition of CQ, the nanoparticle demonstrates improved anticancer efficacy and reduced side effects on normal tissues.

SMALL (2021)

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Review Health Care Sciences & Services

The Enhanced Permeability and Retention (EPR) Effect: The Significance of the Concept and Methods to Enhance Its Application

Jun Wu

Summary: Chemotherapy for human solid tumors faces challenges in delivering anticancer compounds selectively into tumor tissues to maintain effective concentration levels for a certain duration, hindering the execution of anticancer activities. Targeting therapy via the enhanced permeability and retention effect may not always be successful, as it depends on tumor type, location, blood perfusion status, and properties of macromolecular anticancer agents. Efforts to maximize the EPR effect in developing smarter nanomedicines are essential for successful clinical applications.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Materials Science, Biomaterials

A triple-stimulus responsive melanin-based nanoplatform with an aggregation-induced emission-active photosensitiser for imaging-guided targeted synergistic phototherapy/hypoxia-activated chemotherapy

Jie Yu et al.

Summary: A synergistic phototherapy and hypoxia-activated chemotherapy nanoplatform based on melanin nanoparticles was developed, showing favorable photothermal conversion efficiency, desired cytocompatibility, and excellent synergistic therapeutic efficacy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Chemistry, Multidisciplinary

Chemotherapeutic drug-induced immunogenic cell death for nanomedicine-based cancer chemo-immunotherapy

Mingxia Jiang et al.

Summary: The article highlights the importance of inducing immunogenic cell death in tumor cells through chemotherapy drugs, and the promising future and potential of chemo-immunotherapy in cancer treatment.

NANOSCALE (2021)

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Article Nanoscience & Nanotechnology

Glutathione-Responsive Biodegradable Nanoplatform with Endogenous Esterase-Triggered Nitric Oxide Release for Gas Therapy and Enhanced Chemotherapy

Chen Zhang et al.

Summary: An intelligent endogenous esterase-triggered nitric oxide (NO) generator for synergetic cancer therapy was developed by integrating NO prodrug and doxorubicin (DOX) into a single glutathione (GSH)-responsive mesoporous silica nanoparticle (MPND). The system showed stimuli-responsive release of DOX and NO based on endogenic esterase and GSH concentration, resulting in high antitumor efficiency in cancer cells, including deep tumor tissue penetration and enhanced therapeutic effect. This approach may provide a potential alternative strategy for synergistic cancer therapy.

ACS APPLIED BIO MATERIALS (2021)

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Article Materials Science, Biomaterials

Targeted delivery and controlled release of doxorubicin to cancer cells by smart ATP-responsive Y-shaped DNA structure-capped mesoporous silica nanoparticles

Elnaz Bagheri et al.

Summary: In this study, a dual-receptor doxorubicin-targeted delivery system based on mesoporous silica nanoparticles modified with mucine-1 and ATP aptamers was developed, showing high drug loading capacity and ATP-responsive release behavior for enhanced anticancer efficacy. The smart platform exhibited superior tumor accumulation and growth inhibitory effects in vivo, indicating its potential for cancer treatment.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Chemistry, Medicinal

Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review

Nahid S. Awad et al.

Summary: Nano-sized carriers designed for selective delivery of anticancer drugs and genes to tumors can achieve enhanced therapeutic effects by triggering the release of therapeutic drugs through stimuli. Recent research has focused on the application of various stimuli-responsive nanocarriers, showing promising prospects for cancer treatment.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications

Huizhen Zheng et al.

Summary: The combination of nanotechnology with ferroptosis for the treatment of severe diseases has attracted substantial research interest. However, differentiating nanoparticle-induced ferroptosis from other types of cell deaths, elucidating detailed mechanisms, and exploring the key properties of nanoparticles are challenging. Understanding the molecular events and physicochemical properties of nano-inducers involved in ferroptosis is crucial for designing effective nanomaterials for deliberate modulation of ferroptosis.

NANOSCALE (2021)

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Review Oncology

Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression

Reem Saleh et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Self-Amplified Photodynamic Therapy through the 1O2-Mediated Internalization of Photosensitizers from a Ppa-Bearing Block Copolymer

Zhiyong Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Biomedical

Tumor microenvironment-responsive prodrug nanoplatform via co-self-assembly of photothermal agent and IDO inhibitor for enhanced tumor penetration and cancer immunotherapy

Yijia Liu et al.

BIOMATERIALS (2020)

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Article Biophysics

Preparation of polyethylene glycol-polyacrylic acid block copolymer micelles with pH/hypoxic dual-responsive for tumor chemoradiotherapy

Jiajia Weng et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Nanoscience & Nanotechnology

A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy

Chen Xu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Engineering, Biomedical

Bioactivatable reactive oxygen species-sensitive nanoparticulate system for chemo-photodynamic therapy

Yugyeong Kim et al.

ACTA BIOMATERIALIA (2020)

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Review Chemistry, Multidisciplinary

Light-Responsive Inorganic Biomaterials for Biomedical Applications

Hung Pang Lee et al.

ADVANCED SCIENCE (2020)

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Review Chemistry, Multidisciplinary

Application of star poly(ethylene glycol) derivatives in drug delivery and controlled release

Xiaobao Zhao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Ultrasound -responsive polymersomes capable of endosomal escape for efficient cancer therapy

Ping Wei et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Tumor-responsive dynamic nanoassemblies for targeted imaging, therapy and microenvironment manipulation

Liang Ee Low et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

Xinyi Zhang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Review Nanoscience & Nanotechnology

Stimuli-responsive nanotherapeutics for precision drug delivery and cancer therapy

Yiting Qiao et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019)

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Review Chemistry, Multidisciplinary

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Yijing Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Review Biochemistry & Molecular Biology

Cancer Nanotechnology: A New Revolution for Cancer Diagnosis and Therapy

Vivek K. Chaturvedi et al.

CURRENT DRUG METABOLISM (2019)

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Review Oncology

Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma

Xin Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Nanoscience & Nanotechnology

Enzyme-Triggered Morphological Transition of Peptide Nanostructures for Tumor-Targeted Drug Delivery and Enhanced Cancer Therapy

Meiwen Cao et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Physical

Near-Infrared-Light-Responsive Lipid Nanoparticles as an Intelligent Drug Release System for Cancer Therapy

Fei Wang et al.

CHEMISTRY OF MATERIALS (2019)

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Review Oncology

Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer

Georgina Gonzalez-Avila et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

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Article Medicine, Research & Experimental

Novel Class of Ultrasound-Triggerable Drug Delivery Systems for the Improved Treatment of Tumors

Chaopei Zhou et al.

MOLECULAR PHARMACEUTICS (2019)

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Article Chemistry, Multidisciplinary

Organic Semiconducting Pro-nanostimulants for Near-Infrared Photoactivatable Cancer Immunotherapy

Jingchao Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Biochemistry & Molecular Biology

Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System

Huan Ye et al.

BIOMACROMOLECULES (2019)

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Article Chemistry, Multidisciplinary

Transformable Nanoparticle-Enabled Synergistic Elicitation and Promotion of Immunogenic Cell Death for Triple-Negative Breast Cancer Immunotherapy

Chenfeng Xu et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Near-Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis-Inhibited Combination Cancer Therapy

Jingchao Li et al.

ADVANCED MATERIALS (2019)

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Review Chemistry, Medicinal

Prodrugs in combination with nanocarriers as a strategy for promoting antitumoral efficiency

Ming-Hsien Lin et al.

FUTURE MEDICINAL CHEMISTRY (2019)

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Review Chemistry, Multidisciplinary

Enzyme responsive drug delivery systems in cancer treatment

Mahsa Shahriari et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Physiology

The Acidic Tumor Microenvironment as a Driver of Cancer

Ebbe Boedtkjer et al.

Annual Review of Physiology (2019)

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Article Chemistry, Multidisciplinary

Hypoxia-Triggered Transforming Immunomodulator for Cancer Immunotherapy via Photodynamically Enhanced Antigen Presentation of Dendritic Cell

Sooseok Im et al.

ACS NANO (2019)

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Review Pharmacology & Pharmacy

Electric field-responsive nanoparticles and electric fields: physical, chemical, biological mechanisms and therapeutic prospects

Jelena Kolosnjaj-Tabi et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Redox-responsive Fluorescent Nanoparticles Based on Diselenide-containing AIEgens for Cell Imaging and Selective Cancer Therapy

Wenkun Han et al.

CHEMISTRY-AN ASIAN JOURNAL (2019)

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Article Chemistry, Multidisciplinary

Tumor Microenvironment Responsive Drug-Dye-Peptide Nanoassembly for Enhanced Tumor-Targeting, Penetration, and Photo-Chemo-Immunotherapy

Jinrong Peng et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery

Dan Shao et al.

ADVANCED MATERIALS (2018)

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Article Engineering, Biomedical

Photoinduced PEG deshielding from ROS-sensitive linkage-bridged block copolymer-based nanocarriers for on-demand drug delivery

Jie Li et al.

BIOMATERIALS (2018)

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Article Chemistry, Medicinal

Tailor-made pH-sensitive polyacrylic acid functionalized mesoporous silica nanoparticles for efficient and controlled delivery of anti-cancer drug Etoposide

Seema Saroj et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2018)

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Editorial Material Oncology

IMMUNOTHERAPY Cancer immunotherapy and the value of cure

Joseph C. Del Paggio

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Biology

Magnetic nanoparticles based cancer therapy: current status and applications

Huan Zhang et al.

SCIENCE CHINA-LIFE SCIENCES (2018)

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Article Materials Science, Biomaterials

Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer

Mandana Emamzadeh et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Chemistry, Multidisciplinary

PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug

Fan Gao et al.

SMALL (2018)

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Article Biochemical Research Methods

Manipulation of Glutathione-Mediated Degradation of Thiol Maleimide Conjugates

Haocheng Wu et al.

BIOCONJUGATE CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Multiple-Responsive Mesoporous Silica Nanoparticles for Highly Accurate Drugs Delivery to Tumor Cells

Ronghua Jin et al.

ACS OMEGA (2018)

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Article Chemistry, Multidisciplinary

Protease-activatable cell-penetrating peptide possessing ROS-triggered phase transition for enhanced cancer therapy

Jisang Yoo et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Materials Science, Biomaterials

The controlled drug release by pH-sensitive molecularly imprinted nanospheres for enhanced antibacterial activity

Congyang Mao et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Review Biology

Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?

Yanqing Huang et al.

SCIENCE CHINA-LIFE SCIENCES (2017)

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Article Polymer Science

Acetal-Linked Paclitaxel Polymeric Prodrug Based on Functionalized mPEG-PCL Diblock Polymer for pH-Triggered Drug Delivery

Yinglei Zhai et al.

POLYMERS (2017)

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Article Biochemistry & Molecular Biology

Magnetic Fullerene-DNA/Hyaluronic Acid Nanovehicles with Magnetism/Reduction Dual-Responsive Triggered Release

Ling Wang et al.

BIOMACROMOLECULES (2017)

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Article Nanoscience & Nanotechnology

Multifunctional Metal-Organic Framework Nanoprobe for Cathepsin B-Activated Cancer Cell Imaging and Chemo-Photodynamic Therapy

Jintong Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Nanoscience & Nanotechnology

Enzyme and Redox Dual-Triggered Intracellular Release from Actively Targeted Polymeric Micelles

Lei Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Multidisciplinary

Rational Design of Multi-Stimuli-Responsive Nanoparticles for Precise Cancer Therapy

Xiaonan An et al.

ACS NANO (2016)

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Article Chemistry, Multidisciplinary

A Red Light Activatable Multifunctional Prodrug for Image-Guided Photodynamic Therapy and Cascaded Chemotherapy

Li-Han Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2016)

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Article Chemistry, Analytical

A Glutathione (GSH)-Responsive Near-Infrared (NIR) Theranostic Prodrug for Cancer Therapy and Imaging

Fanpeng Kong et al.

ANALYTICAL CHEMISTRY (2016)

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Article Engineering, Biomedical

A surface charge-switchable and folate modified system for co-delivery of proapoptosis peptide and p53 plasmid in cancer therapy

Si Chen et al.

BIOMATERIALS (2016)

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Article Biophysics

pH-sensitive nanocarrier based on gold/silver core-shell nanoparticles decorated multi-walled carbon manotubes for tracing drug release in living cells

Peng Chen et al.

BIOSENSORS & BIOELECTRONICS (2016)

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Article Chemistry, Multidisciplinary

Self-sufficing H2O2-responsive nanocarriers through tumor-specific H2O2 production for synergistic oxidation-chemotherapy

Junjie Li et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Chemistry, Multidisciplinary

Disulfide-Based Multifunctional Conjugates for Targeted Theranostic Drug Delivery

Min Hee Lee et al.

ACCOUNTS OF CHEMICAL RESEARCH (2015)

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Article Nanoscience & Nanotechnology

Amphiphilic Polyelectrolyte/Prodrug Nanoparticles Constructed by Synergetic Electrostatic and Hydrophobic Interactions with Cooperative pH-Sensitivity for Controlled Doxorubicin Delivery

Pingsheng Huang et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Nanoscience & Nanotechnology

Intracellular pH-Triggered, Targeted Drug Delivery to Cancer Cells by Multifunctional Envelope-Type Mesoporous Silica Nanocontainers

Ke Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Chemistry, Multidisciplinary

Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles

Jinping Lai et al.

ACS NANO (2015)

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Review Cardiac & Cardiovascular Systems

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

David I. Brown et al.

CIRCULATION RESEARCH (2015)

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Article Biophysics

A pH- and thermo-responsive poly(amino acid)-based drug delivery system

Na Liu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Article Engineering, Biomedical

Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery

Thavasyappan Thambi et al.

BIOMATERIALS (2014)

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Article Nanoscience & Nanotechnology

pH-responsive polymer-drug conjugates as multifunctional micelles for cancer-drug delivery

Yang Kang et al.

NANOTECHNOLOGY (2014)

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Review Biochemistry & Molecular Biology

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment

A. Casazza et al.

ONCOGENE (2014)

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Article Multidisciplinary Sciences

ATP-triggered anticancer drug delivery

Ran Mo et al.

NATURE COMMUNICATIONS (2014)

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Review Medicine, Research & Experimental

Antibody-Drug Conjugates in Cancer Therapy

Eric L. Sievers et al.

ANNUAL REVIEW OF MEDICINE, VOL 64 (2013)

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Article Chemistry, Medicinal

Visible Light Controlled Release of Anticancer Drug through Double Activation of Prodrug

Abugafar M. L. Hossion et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

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Review Biotechnology & Applied Microbiology

Glutathione levels in human tumors

Michael P. Gamcsik et al.

BIOMARKERS (2012)

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Review Oncology

Immunogenic cell death and DAMPs in cancer therapy

Dmitri V. Krysko et al.

NATURE REVIEWS CANCER (2012)

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Article Chemistry, Multidisciplinary

Squalene Based Nanocomposites: A New Platform for the Design of Multifunctional Pharmaceutical Theragnostics

Jose L. Arias et al.

ACS NANO (2011)

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Article Chemistry, Multidisciplinary

Magnetic Nanocarriers with Tunable pH Dependence for Controlled Loading and Release of Cationic and Anionic Payloads

Nadja C. Bigall et al.

ADVANCED MATERIALS (2011)

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Review Oncology

Regulation of cancer cell metabolism

Rob A. Cairns et al.

NATURE REVIEWS CANCER (2011)

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Review Biotechnology & Applied Microbiology

Stimulus-responsive targeted nanomicelles for effective cancer therapy

Madaswamy S. Muthu et al.

NANOMEDICINE (2009)

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