期刊
NEUROSCIENCE LETTERS
卷 625, 期 -, 页码 47-55出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.02.013
关键词
Mitochondria; DNA methylation; Epigenetics; mtDNA; Alzheimer's disease; AD
资金
- Alzheimers Research UK [ARUK-PPG2013A-5] Funding Source: researchfish
- NIA NIH HHS [R01 AG036039] Funding Source: Medline
The field of mitochondrial epigenetics has received increased attention in recent years and changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis. However, current publications have been limited by the use of global or targeted methods of measuring DNA methylation. In this review, we discuss current findings in mitochondrial epigenetics as well as its potential role as a regulator of mitochondria within the brain. Finally, we summarize the current technologies best suited to capturing mtDNA methylation, and how a move towards whole epigenome sequencing of mtDNA may help to advance our current understanding of the field. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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