期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 69, 期 -, 页码 381-401出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.08.012
关键词
Anterior cingulate cortex; Basal ganglia; Frontal; Amotivation; Apathy; Electroencephalography (EEG); Magnetic resonance imaging (MRI); Neuroimaging; Parietal; Positron emission tomography (PET); Single photon emission computed tomography (SPELT); Striatum
资金
- VICI grant from the Netherlands Organisation for Scientific Research (N.W.O.) [453.11.004]
- ERC [312787]
- VENI grant from the Netherlands Organization for Scientific Research (N.W.O.) [016.156.077]
- European Research Council (ERC) [312787] Funding Source: European Research Council (ERC)
Apathy can be described as a loss of goal-directed purposeful behavior and is common in a variety of neurological and psychiatric disorders. Although previous studies investigated associations between abnormal brain functioning and apathy, it is unclear whether the neural basis of apathy is similar across different pathological conditions. The purpose of this systematic review was to provide an extensive overview of the neuroimaging literature on apathy including studies of various patient populations, and evaluate whether the current state of affairs suggest disorder specific or shared neural correlates of apathy. Results suggest that abnormalities within fronto-striatal circuits are most consistently associated with apathy across the different pathological conditions. Of note, abnormalities within the inferior parietal cortex were also linked to apathy, a region previously not included in neuroanatomical models of apathy. The variance in brain regions implicated in apathy may suggest that different routes towards apathy are possible. Future research should investigate possible alterations in different processes underlying goal-directed behavior, ranging from intention and goal-selection to action planning and execution. (C) 2016 Published by Elsevier Ltd.
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