期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 68, 期 -, 页码 694-713出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.06.040
关键词
Mitochondria; Bipolar disorder; Mania; Depression; Mitochondrial dysfunction; Oxidative stress; Inflammation; Apoptosis; Neurogenesis
资金
- Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston
- CNPq
- FAPESC
- Instituto Cerebro e Mente
- UNESC
- NHMRC [1059660]
- NIH
- Cooperative Research Centre
- Simons Autism Foundation
- Cancer Council of Victoria
- Stanley Medical Research Foundation
- MBF
- Beyond Blue
- Rotary Health
- Geelong Medical Research Foundation
- Bristol-Myers Squibb
- Eli Lilly
- GlaxoSmithKline
- Meat and Livestock Board
- Organon
- Novartis
- Mayne Pharma
- Servier
- Woolworths
Bipolar disorder (BD) is a chronic psychiatric illness characterized by severe and biphasic changes in mood. Several pathophysiological mechanisms have been hypothesized to underpin the neurobiology of BD, including the presence of mitochondrial dysfunction. A confluence of evidence points to an underlying dysfunction of mitochondria, including decreases in mitochondrial respiration, high-energy phosphates and pH; changes in mitochondrial morphology; increases in mitochondrial DNA polymorphisms; and downregulation of nuclear mRNA molecules and proteins involved in mitochondrial respiration. Mitochondria play a pivotal role in neuronal cell survival or death as regulators of both energy metabolism and cell survival and death pathways. Thus, in this review, we discuss the genetic and physiological components of mitochondria and the evidence for mitochondrial abnormalities in BD. The final part of this review discusses mitochondria as a potential target of therapeutic interventions in BD. (C) 2016 Elsevier Ltd. All rights reserved.
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