期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 66, 期 -, 页码 15-32出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.03.030
关键词
Cocaine addiction vulnerability; Therapeutic approach; Cognition; Emotion; Habits; Brain functional networks; Hippocampal plasticity; Magnetic resonance imaging; Self-administration; Conditioned place preference
资金
- Spanish Ministry of Economy and Competitiveness
- European Research Development Fund (UE-ERDF) [PSI2013-44901-P]
- Regional Ministry of Health and Social Welfare of the Andalusian Regional Government (Junta de Andalucia) [PI0228-2013, PI0823-2012]
- Red de Trastornos Adictivos UE-ERDF [RD12/0028/0001]
- Plan Nacional sobre Drogas [049/2013]
- National System of Health, ISC-III [CD12/00455, CP12/03109, CP14/00212, CP14/00173]
Cocaine addiction is a chronic brain disease in which the drug seeking habits and profound cognitive, emotional and motivational alterations emerge from drug-induced neuroadaptations on a vulnerable brain. Therefore, a 'cocaine addiction brain circuit' has been described to explain this disorder. Studies in both cocaine patients and rodents reveal the hippocampus as a main node in the cocaine addiction circuit. The contribution of the hippocampus to cocaine craving and the associated memories is essential to understand the chronic relapsing nature of addiction, which is the main obstacle for the recovery. Interestingly, the hippocampus holds a particular form of plasticity that is rare in the adult brain: the ability to generate new functional neurons. There is an active scientific debate on the contributions of these new neurons to the addicted brain. This review focuses on the potential role(s) of adult hippocampal neurogenesis (AHN) in cocaine addiction. Although the current evidence primarily originates from animal research, these preclinical studies support AHN as a relevant component for the hippocampal effects of cocaine. (C) 2016 Elsevier Ltd. All rights reserved.
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