期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 68, 期 -, 页码 442-453出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.06.013
关键词
Autism spectrum disorders (ASD); Neurodevelopment; Genome sequencing; Systems biology; Brain gene expression
资金
- University of Queensland
- Australian Research Council [FT110100292]
- National Health and Medical Research Council [APP1008125]
- Australian Research Council [FT110100292] Funding Source: Australian Research Council
The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major challenge. Recent advances in genetic screening and systems biology approaches have extended our knowledge of the genetic etiology of ASD. In this review, we discuss the paradigm shift from a single gene causation model to pathway perturbation model as a guide to better understand the pathophysiology of ASD. We discuss recent genetic findings obtained through next-generation sequencing (NGS) and examine various integrative analyses using systems biology and complex networks approaches that identify convergent patterns of genetic elements associated with ASD. (C) 2016 Elsevier Ltd. All rights reserved.
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