期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 66, 期 -, 页码 33-53出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.03.032
关键词
Ghrelin; Endocannabinoids; Interaction; GHSRs; CB-1Rs; VTA; Food intake; Adiposity
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) [315801]
- Canadian Institutes of Health Research (CIHR)
- NSERC Post Graduate Scholarship
- Ontario Graduate Scholarship (OGS)
Independent stimulation of either the ghrelin or endocannabinoid system promotes food intake and increases adiposity. Given the similar distribution of their receptors in feeding associated brain regions and organs involved in metabolism, it is not surprising that evidence of their interaction and its importance in modulating energy balance has emerged. This review documents the relationship between ghrelin and endocannabinoid systems within the periphery and hypothalamus (HYP) before presenting evidence suggesting that these two systems likewise work collaboratively within the ventral tegmental area (VTA) to modulate non-homeostatic feeding. Mechanisms, consistent with current evidence and local infrastructure within the VTA, will be proposed. (C) 2016 Elsevier Ltd. All rights reserved.
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