期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 71, 期 -, 页码 680-690出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.10.007
关键词
Hippocampus; Clinical high-risk; Biomarker; Magnetic resonance imaging; At-risk mental state; Ultra high-risk; Psychosis; Early detection
Several magnetic resonance imaging studies have reported reductions in hippocampal volume in patients with psychosis. It is unclear whether structural abnormalities predate illness onset. We conducted a detailed, systematic literature search for studies reporting hippocampal volume in subjects with clinical high-risk, compared to healthy controls. The overall sample size comprised 1429 subjects. Meta-analysis revealed no difference for left, but a small, albeit significant, difference for right hippocampal volume, such that clinical high-risk patients had slightly smaller hippocampal volume than healthy controls (g = 0.24, p = 0.0418). Meta-regression indicated a moderating effect of manual tracing approach, due to one outlying site. The small difference on the right side did not remain significant (g = 0.14, 95%CI = [-0.03-0.32], p=0.11) after removal of this outlier. This meta-analysis suggests that there is no reduction in hippocampal volume before transition to psychosis and hippocampal volume cannot be used as a biomarker in clinical high-risk individuals. (C) 2016 Elsevier Ltd. All rights reserved.
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