期刊
NEUROSCIENCE
卷 323, 期 -, 页码 35-42出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2015.05.002
关键词
astroglial cells; tripartite synapse; cannabinoid receptors; synaptic plasticity; working memory
资金
- INSERM
- EU-Fp7 (PAINCAGE) [HEALTH-603191]
- European Research Council [ERC-2010-St G-260515, ERC-2014-PoC-640923]
- Fondation pour la Recherche Medicale [DRM20101220445]
- Human Frontiers Science Program
- International PhD School of the University of Catania Region Aquitaine
- BRAIN [ANR-10-LABX-0043]
The endocannabinoid system is an important regulator of physiological functions. In the brain, this control is mainly exerted through the type-1-cannabinoid (CB1) receptors. CB1 receptors are abundant at neuron terminals where their stimulation inhibits neurotransmitter release. However, CB1 receptors are also expressed in astrocytes and recent studies showed that astroglial cannabinoid signaling is a key element of the tripartite synapse. In this review we discuss the different mechanisms by which astroglial CB1 receptors control synaptic transmission and plasticity. The recent involvement of astroglial CB1 receptors in the effects of cannabinoids on memory highlights their key roles in cognitive processes and further indicates that astrocytes are central active elements of high-order brain functions. This article is part of a Special Issue entitled: Astrocyte-Neuron Interact. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
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