4.4 Article

Oxytocin Attenuates Yohimbine-Induced Reinstatement of Alcohol-Seeking in Female Rats via the Central Amygdala

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Male-selective effects of oxytocin agonism on alcohol intake: behavioral assessment in socially housed prairie voles and involvement of RAGE

Sheena Potretzke et al.

Summary: This study examined the behavioral and molecular effects of targeting the oxytocin receptor (OXTR) in prairie voles for the treatment of alcohol use disorder (AUD). The results showed that intranasal administration of oxytocin selectively inhibited alcohol drinking in male prairie voles and that exogenous oxytocin penetrated the prairie vole brain. In addition, a small-molecule OXTR agonist was found to inhibit alcohol intake in male prairie voles. These findings support the potential of selectively targeting OXTR for individualized treatment of AUD.

NEUROPSYCHOPHARMACOLOGY (2023)

Article Psychiatry

Anxiolytic Effects of Chronic Intranasal Oxytocin on Neural Responses to Threat Are Dose-Frequency Dependent

Juan Kou et al.

Summary: This study investigated the effects of low-dose frequency chronic intranasal oxytocin (OT) on individuals with high trait anxiety. The results showed that low-frequency chronic dosage of OT attenuated neural reactivity to threatening stimuli, suggesting a potential treatment for anxiety disorders.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2022)

Editorial Material Biochemistry & Molecular Biology

No changes in the oxytocin system in alcohol-dependent female rodents and humans: Towards a sex-specific psychopharmacology in alcoholism

Anita C. Hansson et al.

Summary: A recent study found a decrease in oxytocin levels and an increase in oxytocin receptor binding sites in male alcohol dependent rats and patients, but no changes in the oxytocin system were observed in female alcohol dependent rats and humans. Therefore, it is recommended to specifically intervene with oxytocin only in male subjects.

ADDICTION BIOLOGY (2021)

Article Neurosciences

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Jerome Wahis et al.

Summary: This study reveals a morphologically distinct subpopulation of astrocytes expressing OT receptors in the central amygdala of mice and rats, mediating the anxiolytic and positive reinforcement effects of OT. It challenges the traditional belief that OT exclusively acts on neurons, highlighting the essential role of astrocytes in modulating emotional states under normal and chronic pain conditions.

NATURE NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Oxytocin Attenuates the Stress-Induced Reinstatement of Alcohol-Seeking in Male Rats: Role of the Central Amygdala

Hannah S. Ballas et al.

Summary: Factors such as stress and anxiety can trigger alcohol-dependent behavior and relapse, and investigating potential pharmacological interventions is important. Previous studies suggest that oxytocin has anxiolytic potential and can disrupt stress-induced ethanol-seeking behavior, specifically within the central amygdala.

BIOMEDICINES (2021)

Article Endocrinology & Metabolism

Oxytocin and social anxiety: Interactions with sex hormones

E. Schneider et al.

Summary: The study found that women with high endogenous oxytocin and estradiol levels reported lower social anxiety levels, and this hormonal interaction with social anxiety scores was more significant in high socially anxious women.

PSYCHONEUROENDOCRINOLOGY (2021)

Article Behavioral Sciences

Voluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice

Karla M. Rodriguez et al.

BRAIN AND BEHAVIOR (2020)

Article Behavioral Sciences

Selective sub-nucleus effects of intra-amygdala oxytocin on fear extinction

Ozge Gunduz-Cinar et al.

BEHAVIOURAL BRAIN RESEARCH (2020)

Article Neurosciences

Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans

Anita C. Hansson et al.

NEUROPSYCHOPHARMACOLOGY (2018)

Article Psychology, Biological

Distress Tolerance and Physiological Reactivity to Stress Predict Women's Problematic Alcohol Use

Cathryn Glanton Holzhauer et al.

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY (2017)

Article Substance Abuse

Oxytocin Reduces Ethanol Self-Administration in Mice

Courtney E. King et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2017)

Article Biochemistry & Molecular Biology

Sex differences in substance use disorders: focus on side effects

Roberta Agabio et al.

ADDICTION BIOLOGY (2016)

Article Biochemistry & Molecular Biology

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

Kun Li et al.

Article Psychology, Biological

Oxytocin Decreases Cocaine Taking, Cocaine Seeking, and Locomotor Activity in Female Rats

Kah-Chung Leong et al.

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY (2016)

Article Behavioral Sciences

Peripheral oxytocin administration reduces ethanol consumption in rats

Kaley MacFadyen et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2016)

Article Endocrinology & Metabolism

Oxytocin receptor gene variation rs53576 and alcohol abuse in a longitudinal population representative study

Mariliis Vaht et al.

PSYCHONEUROENDOCRINOLOGY (2016)

Review Neurosciences

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

Nicholas W. Gilpin et al.

BIOLOGICAL PSYCHIATRY (2015)

Article Neurosciences

Oxytocin's role in anxiety: A critical appraisal

Kai MacDonald et al.

BRAIN RESEARCH (2014)

Article Endocrinology & Metabolism

Sex differences in methamphetamine seeking in rats: Impact of oxytocin

Brittney M. Cox et al.

PSYCHONEUROENDOCRINOLOGY (2013)

Review Endocrinology & Metabolism

Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour

T. Onaka et al.

JOURNAL OF NEUROENDOCRINOLOGY (2012)

Article Clinical Neurology

Anxiolytic-like effect of oxytocin in the simulated public speaking test

Danielle C. G. de Oliveira et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2012)

Article Multidisciplinary Sciences

Genetic dissection of an amygdala microcircuit that gates conditioned fear

Wulf Haubensak et al.

NATURE (2010)

Article Neurosciences

A Neural Switch for Active and Passive Fear

Alessandro Gozzi et al.

NEURON (2010)

Article Endocrinology & Metabolism

A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder

Adam J. Guastella et al.

PSYCHONEUROENDOCRINOLOGY (2009)

Article Behavioral Sciences

Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking

Nicholas W. Gilpin et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2008)