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Article
Clinical Neurology
Nicholas M. Gregg et al.
Summary: This study investigated the relationships between various physiological signals, brain activity, and seizure timing using multimodal wearable devices. The findings showed that seizure timing is associated with daily and multiday cycles in multiple physiological processes. This research contributes to a better understanding of factors influencing seizure risk and provides a time-varying approach for personalized epilepsy care.
Article
Clinical Neurology
Chris Serrand et al.
Summary: A case-control study was conducted to identify risk factors for sudden unexpected death in epilepsy (SUDEP) and develop a risk score for prevention. The study found that generalized and nocturnal seizures increased the risk of SUDEP, while the ability to alert someone of an oncoming seizure was protective. The developed SUDEP-CARE score showed good discrimination capabilities and will require external validation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Andreas Schulze-Bonhage et al.
Summary: A pooled analysis of two clinical trials showed that a novel stimulation device could effectively reduce seizure frequency in patients with drug-refractory focal epilepsy, providing a promising treatment option for patients with a predominant epileptic focus.
Article
Clinical Neurology
Andreas Schulze-Bonhage et al.
Summary: This study investigates the validity of patient reported seizures in reflecting the cyclical occurrence of seizures. The results show that patient reports of seizures exhibit cyclical underreporting, especially during nighttime, leading to significant deviations in the circadian distribution of seizures. This suggests that patient reported seizures may have a cyclical reporting bias, highlighting the importance of using objective measures to monitor the cyclical distribution of seizures.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Sharon Chiang et al.
Summary: Approximately 8 months of chronic RNS ECoG are needed to precisely estimate the seizure laterality ratio in patients with drug-resistant BTLE, with 75% of patients achieving convergence after 1 year of recording. Optimized recording duration may help avoid morbidity associated with delay to definitive treatment for individuals who are candidates for unilateral resection based on seizure laterality.
Article
Clinical Neurology
Andreas Schulze-Bonhage et al.
Summary: This study aimed to determine the diagnostic yield of in-hospital video-EEG monitoring for seizures in patients with epilepsy. The results showed that the duration of monitoring was highly associated with seizure recordings, and presurgical patients and patients with drug reduction had a higher diagnostic yield. In addition, monitoring for more than 5 days only led to less than 10% of patients having additional new seizure documentation.
Review
Medicine, General & Internal
Mariangela Panebianco et al.
Summary: This study evaluated the efficacy and tolerability of vagus nerve stimulation (VNS) as an adjunctive therapy for drug-resistant focal epilepsy. The results suggest that high-frequency VNS is more effective than low-frequency VNS, and the common adverse effects include hoarseness, cough, dyspnoea, pain, and paraesthesia. However, the evidence for these outcomes is limited, and further research is needed.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Clinical Neurology
Pedro F. Viana et al.
Summary: Ultra long-term subcutaneous electroencephalography (sqEEG) monitoring is a new modality with great potential for both health and disease, including epileptic seizure detection and forecasting. The spectral characteristics of minimally invasive, ultra long-term sqEEG are similar to scalp EEG, whereas the signal is highly stationary. Our findings reinforce the suitability of this system for chronic implantation on diverse clinical applications, from seizure detection and forecasting to brain-computer interfaces.
Article
Clinical Neurology
Rachel E. Stirling et al.
Summary: Accurate identification of seizure activity is crucial for epilepsy management. Using a minimally invasive sub-scalp device for recording EEG data has shown promise in accurately detecting seizures and forecasting them.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Maxime O. Baud et al.
Summary: The cyclical structure of epilepsy has been recently rediscovered through long-term intracranial electroencephalography obtained with implanted devices, providing new insights into the practice and interpretation of conventional EEG. There are caveats to counting epileptiform discharges in short-duration EEG recordings and the limitations of conventional EEG have practical implications for titrating anti-seizure medications and allowing patients to drive. Chronic monitoring of brain activity could greatly improve epilepsy care, and utilizing next-generation devices for chronic EEG could leverage known biomarkers of disease state in an impending paradigm shift in epilepsy care.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2021)
Article
Clinical Neurology
Lawrence J. Hirsch et al.
Article
Clinical Neurology
Helena Mielke et al.
Review
Clinical Neurology
Jonas Duun-Henriksen et al.
Article
Clinical Neurology
Sigge Weisdorf et al.
Article
Clinical Neurology
Joon Y. Kang et al.
Review
Medicine, General & Internal
Andreas Schulze-Bonhage et al.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2014)
Article
Engineering, Biomedical
Felice T. Sun et al.
EXPERT REVIEW OF MEDICAL DEVICES
(2014)
