期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 6, 页码 1277-1282出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201401146
关键词
C(sp(3))-H activation; monofluoromethylation; photoredox catalytic; tetrahydroisoquinolines.; visible light
资金
- Nature National Science Foundation of China [21172106, 21074054, 21372114]
- National Basic Research Program of China [2010CB923303]
- Research Fund for the Doctoral Program of Higher Education of China [20120091110010]
A visible-light photoredox-catalyzed reaction of tetrahydroisoquinolines with beta-fluorinated gem-diols results in the formation of C1-monofluoromethylated tetrahydroisoquinolines via C(sp(3))-H bond activation. This protocol provides a new method to introduce a CF group with stable, easily-prepared monofluorinated gem-diol as CF source. A mechanistic investigation is presented based on control experiments.
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