期刊
NEUROSCIENCE
卷 338, 期 -, 页码 220-229出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2016.08.014
关键词
insular cortex; synaptic plasticity; long-term potentiation; chronic pain; long-term depression; adenylyl cyclase
资金
- Canadian Institute for Health Research [258523]
- NSERC (Natural Sciences and Engineering Research Council of Canada) discovery grant [RGPIN 402555]
- Azrieli Foundation and Brain Canada
Animal and human studies have consistently demonstrated that cortical regions are important for pain perception and pain-related emotional changes. Studies of the anterior cingulate cortex (ACC) have shown that adult cortical synapses can be modified after peripheral injuries, and long-term changes at synaptic level may contribute to long-lasting suffering in patients. It also explains why chronic pain is resistant to conventional analgesics that act by inhibiting synaptic transmission. Insular cortex (IC), another critical cortical area, is found to be highly plastic and can undergo long-term potentiation (LTP) after injury. Inhibiting IC LTP reduces behavioral sensitization caused by injury. LTP of glutamatergic transmission in pain related cortical areas serves as a key mechanism for chronic pain. This article is part of a Special Issue entitled: Pain. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
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