☆ 4.3 Review

The Application of Biomedicine in Chemodynamic Therapy: From Material Design to Improved Strategies

BIOENGINEERING-BASEL (2023)

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Review Engineering, Environmental

Nanomaterials-modulated Fenton reactions: Strategies, chemodynamic therapy and future trends

Junjie Qi et al.

Summary: The Fenton reaction, catalyzed by ferrous ions, decomposes hydrogen peroxide to generate hydroxyl radicals. In this review, the mechanisms, strategies, and biological applications of nanomaterial-modulated Fenton reaction are summarized. The challenges and future directions of NMM-Fenton and its applications in chemodynamic therapy are described.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Engineering, Biomedical

GSH-Responsive Organosilica Hybrid Nanosystem as a Cascade Promoter for Enhanced Starvation and Chemodynamic Therapy

Huan Wu et al.

Summary: In this study, a glutathione-responsive organosilica hybrid micelle system was developed for enhanced starvation therapy and chemodynamic therapy. The system utilizes the catalytic activity of glucose oxidase to consume glucose and oxygen within tumor cells, generating hydrogen peroxide which is then decomposed to release oxygen. Simultaneously, the system can deplete glutathione in the tumor microenvironment and catalyze hydrogen peroxide to generate highly toxic hydroxyl radicals for chemodynamic therapy. The results demonstrate the significant antitumor efficacy of this system in both in vitro and in vivo experiments.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Engineering, Environmental

Programmable phthalocyanine-iron-based nanoreactor for fluorescence/magnetic resonance dual-modality imaging-guided sono/chemodynamic therapies

Dong Li et al.

Summary: In this study, a novel nanoreactor FeS2@PcD, programmatically regulated by the bivariate factors of H+ and H2O2 in the tumor microenvironment (TME), was designed for specific fluorescence and MR dual-modality imaging-guided sono/chemodynamic therapies, representing a promising precision medicine approach.

CHEMICAL ENGINEERING JOURNAL (2023)

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Review Chemistry, Multidisciplinary

A review on reactive oxygen species (ROS)-inducing nanoparticles activated by uni- or multi-modal dynamic treatment for oncotherapy

Jinyong Lin et al.

Summary: Cancer cells are more susceptible to oxidative stress and nanomaterials-based therapies that generate reactive oxygen species (ROS) have been effective in eliminating cancer cells. These therapies, including chemodynamic therapy, photodynamic therapy, sonodynamic therapy, as well as multi-modal therapies such as combination therapy, have shown significant inhibition of tumor growth. However, the limitations of multi-modal therapy in material preparation and operation protocols hinder its clinical application. Cold atmospheric plasma (CAP), as a reliable source of ROS, light, and electromagnetic fields, provides a simple alternative for implementing multi-modal treatments. Therefore, the emerging field of tumor precision medicine is expected to benefit from these promising multi-modal therapies based on ROS-generating nanomaterials and reactive media like CAPs.

NANOSCALE (2023)

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Article Chemistry, Multidisciplinary

Guiding Transition Metal-Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi-Enzymatic Activities for Intensive Chemodynamic Therapy

Shuming Dong et al.

Summary: The authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities to disrupt the H2O2 homeostasis, achieve intensive NCDT, and induce tumor apoptosis and death. The nanozyme catalyzes the conversion of superoxide anion into H2O2 in the tumor region and inhibits the off-target decomposition of H2O2. The elevated H2O2 is then converted into toxic hydroxyl radicals, leading to tumor cell death.

ADVANCED MATERIALS (2022)

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Article Engineering, Environmental

Juglone-loaded metal-organic frameworks for H2O2 self-modulating enhancing chemodynamic therapy against prostate cancer

Long Zhao et al.

Summary: This study developed a Fe-based metal-organic framework as a carrier for the drug Juglone to enhance the CDT efficacy by increasing intracellular H2O2 concentration and inhibiting Pin1. The released Fe ions trigger the Fenton reaction to produce cytotoxic hydroxyl radical, achieving significant antitumor effects. The results demonstrate the potential of drug/CDT synergistic therapy for cancer treatment.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Chemistry, Multidisciplinary

Magnetic-Optical Imaging for Monitoring Chemodynamic Therapy

Youjuan Wang et al.

Summary: Chemodynamic therapy utilizes reactive oxygen species generated by endogenous triggers in the tumor microenvironment to kill cancer cells. Despite the recent progress in this field, challenges such as unknown catalytic activity of therapy reagents and unpredictable treatment effects still exist. It is necessary to reveal the therapeutic mechanism of chemodynamic therapy and develop self-monitoring probes to address these challenges.

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES (2022)

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Article Biophysics

Synergistic anticancer theragnostic study of a core-shell structured galvanic cell

Bao Jiang et al.

Summary: Researchers have successfully synthesized a core-shell CDT drug FeCNB, which achieves high-efficiency CDT under physiological pH conditions through the galvanic cell structure formed in physiological electrolyte solution. FeCNB not only has T2-magnetic resonance imaging function and photothermal conversion ability, but also improves the CDT effect through tumor heating to achieve a satisfactory synergistic photothermal therapy (PTT)/CDT outcome.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Chemistry, Physical

Multifunctional carbon quantum dots as a theranostic nanomedicine for fluorescence imaging-guided glutathione depletion to improve chemodynamic therapy

Jun Li et al.

Summary: A novel theranostic nanomedicine Fe-CD was developed for fluorescence imaging-guided GSH depletion and cancer therapy in the tumor microenvironment. Fe-CD not only generated abundant hydroxyl radicals under H2O2 but also monitored successful GSH depletion through fluorescence imaging, enhancing the effect of chemodynamic therapy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Chemodynamic Therapy via Fenton and Fenton-Like Nanomaterials: Strategies and Recent Advances

Chenyang Jia et al.

Summary: Chemodynamic therapy (CDT) is a novel cancer treatment strategy that generates hydroxyl radicals in the tumor region using Fenton or Fenton-like reactions. It has advantages such as low side effects, independence from external stimulation, modulation of the tumor microenvironment, and low treatment cost. CDT can also be combined with other therapies to enhance anticancer effects.

SMALL (2022)

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Article Chemistry, Multidisciplinary

An Ultrasmall Fe3O4-Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH-Depleted Cascade Redox Reactions for Intensive Wound Disinfection

Jiayu Xiao et al.

Summary: This study demonstrates a smart nanozyme that efficiently consumes GSH, provides abundant H2O2, and ultimately enhances the antibacterial performance of CDT through photothermal effects and cascade catalytic reactions. The nanozyme exhibits excellent antibacterial properties against both Staphylococcus aureus and Escherichia coli.

SMALL (2022)

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Review Cell & Tissue Engineering

Nanozyme-Based Enhanced Cancer Immunotherapy

Ngoc Man Phan et al.

Summary: Catalytic nanoparticles with enzyme-mimicking properties, known as nanozymes, have emerged as promising candidate materials for cancer immunotherapy. By utilizing their enzymatic activities, nanozymes can modulate the tumor microenvironment and enhance the efficacy of cancer immunotherapy.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2022)

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Article Engineering, Biomedical

γ-Fe2O3 Loading Mitoxantrone and Glucose Oxidase for pH-Responsive Chemo/Chemodynamic/Photothermal Synergistic Cancer Therapy

Zhihao Zhong et al.

Summary: This study presents a new therapeutic nanoplatform for synergistic cancer therapy using photoacoustic imaging-guided chemo/chemodynamic/photothermal (CT/CDT/PTT) approaches. The synthesized nanoplatform showed selective accumulation at tumor sites and demonstrated significant synergistic therapeutic effects in vitro and in vivo.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

A Metabolic Multistage Glutathione Depletion Used for Tumor-Specific Chemodynamic Therapy

Ying Huang et al.

Summary: In this study, a multistage chemodynamic therapy (CDT) specific to tumor cells is proposed, which can efficiently deplete the high glutathione (GSH) content in tumor cells. By consuming reserved GSH and inhibiting GSH synthesis in cancer cells, the CDT achieves potent GSH exhaustion. The glycolysis inhibitor used in this study not only increases the sensitivity of tumor cells to CDT, but also stimulates a protective mode in normal cells. This tumor-specific CDT utilizes the responsiveness of the glycolysis inhibitor and nanocarrier to the tumor microenvironment.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Genetically Engineered Nanohyaluronidase Vesicles: A Smart Sonotheranostic Platform for Enhancing Cargo Penetration of Solid Tumors

Shuyu Xu et al.

Summary: This study presents a bioengineering-based smart enzymatic nanovesicle system, mHAase@nP18, which degrades the main component of tumor microenvironment hyaluronic acid (HA) to enhance tumor penetration and alleviate hypoxia, leading to enhanced sonodynamic therapy (SDT) effect.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Multidisciplinary Sciences

Cascade-responsive nanobomb with domino effect for anti-tumor synergistic therapies

Yang Liu et al.

Summary: In this study, a cascade-responsive ROS nanobomb was designed to selectively generate multiple powerful ROS storms at tumor sites without external stimulation, thus effectively activating anti-tumor immune response.

NATIONAL SCIENCE REVIEW (2022)

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Article Engineering, Biomedical

?-Fe2O3 based nanotherapeutics for near-infrared/dihydroartemisinin dual-augmented chemodynamic antibacterial therapy

Yueying Xu et al.

Summary: Chemodynamic therapy (CDT) is a promising treatment for bacterial infection. However, its therapeutic efficiency is hindered by various factors. In this study, researchers developed a nanotherapeutic agent for enhanced antibacterial CDT using NIR/DHA dual-augmentation. The results showed that the agent had satisfactory photothermal and peroxidase-like activities, and exhibited pH-responsive release behavior. In vitro and in vivo experiments demonstrated its effective bactericidal and anti-inflammatory abilities. These findings suggest that the developed nanotherapeutic agent has potential for clinical use.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Multidisciplinary

Extended Conjugation Tuning Carbon Nitride for Non-sacrificial H2O2 Photosynthesis and Hypoxic Tumor Therapy

Jin Ma et al.

Summary: This study reports a C5N2 photocatalyst with a conjugated C=N linkage for selective and efficient non-sacrificial production of H2O2. The photocatalyst exhibits high solar-to-chemical conversion efficiency and the highest activity under hypoxic conditions. Additionally, the study demonstrates the outstanding performance of C5N2 in hypoxic PDT/CDT.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Materials Science, Biomaterials

Dual-activity nanozyme to initiate tandem catalysis for doubly enhancing ATP-depletion anti-tumor therapy

Cong Cong et al.

Summary: This study reports a rarely discovered nanozyme ruthenium (Ru) with double catalytic activity of glucose-oxidase-like (GOx-like) activity and peroxidase-like (POD-like) activity. By combining with atovaquone (ATO) to form nanoparticles, this Ru nanozyme can achieve continuous anti-tumor therapy in the tumor microenvironment. This research provides a basis for further exploration of the activity and application of Ru nanozyme in anti-tumor treatment.

BIOMATERIALS ADVANCES (2022)

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Article Materials Science, Biomaterials

Multifunctional nanosystems sequentially regulating intratumor Fenton chemistry by remodeling the tumor microenvironment to reinforce chemodynamic therapy

Kai Dong et al.

Summary: This study reported a multifunctional nanosystem, TPI@PPCAI, which remodeled the tumor microenvironment to achieve efficient chemodynamic therapy. The results demonstrated that TPI@PPCAI achieved high-efficiency CDT on xenograft MDA-MB-231 tumor-bearing mice, offering a novel approach for ROS-mediated therapy.

BIOMATERIALS ADVANCES (2022)

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Article Chemistry, Inorganic & Nuclear

A targeted and efficient CDT system with photocatalytic supplement of H2O2 and hydroxyl radical production at a neutral pH

Xuwen Da et al.

Summary: In this study, a new approach using old compounds was developed to overcome the bottleneck problems in chemodynamic therapy (CDT). By harnessing photo-catalysis and conversion reactions, a highly efficient, selective, and photo-controlled CDT system was successfully constructed.

INORGANIC CHEMISTRY FRONTIERS (2022)

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Article Nanoscience & Nanotechnology

Macrophage-Mimic Hollow Mesoporous Fe-Based Nanocatalysts for Self-Amplified Chemodynamic Therapy and Metastasis Inhibition via Tumor Microenvironment Remodeling

Wenbao Zuo et al.

Summary: Fe-based nanomaterials with Fenton reaction activity show promise for tumor-specific chemodynamic therapy (CDT). However, low catalytic efficiency and high tumor intracellular pH have limited their clinical application. In this study, macrophage membrane-camouflaged hollow mesoporous ferric oxide (HMFe) nanocatalysts loaded with a carbonic anhydrase IX inhibitor (CAI) were developed to remodel the tumor microenvironment and enhance CDT. The HMFe acted as a Fenton agent with high active-atom exposure, while also providing a hollow cavity for CAI loading. The macrophage membrane-camouflaging improved immune evasion and tumor-specific accumulation, enabling self-amplified CDT and inhibition of tumor metastasis.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Chemistry, Inorganic & Nuclear

Sonodynamic and chemodynamic therapy based on organic/organometallic sensitizers

Yongxin He et al.

Summary: ROS play a role in tumor development under oxidative stress, with PDT and SDT being novel methods of cancer treatment. SDT utilizes sound waves to trigger sonosensitizers for cancer treatment, with therapeutic efficiency linked to the molecular structures and performances of sonosensitizers.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Nanoscience & Nanotechnology

Pillar[6]arene-Based Supramolecular Nanocatalysts for Synergistically Enhanced Chemodynamic Therapy by the Intracellular Cascade Reaction

Xin Liu et al.

Summary: Chemodynamic therapy (CDT) based on the intracellular Fenton reaction is a promising approach for cancer treatment. This study introduces a novel supramolecular nanocatalyst, GOx@T-NPs, which exhibits high efficiency in converting glucose into hydroxyl radicals and enhancing the CDT effect. Furthermore, GOx@T-NPs demonstrate excellent biocompatibility, tumor selectivity, and trimodal synergistic interactions for efficient cancer therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Macrophage Membrane-Camouflaged Responsive Polymer Nanogels Enable Magnetic Resonance Imaging-Guided Chemotherapy/Chemodynamic Therapy of Orthotopic Glioma

Tingting Xiao et al.

Summary: The study introduces a multifunctional polymer nanogel camouflaged with macrophage membranes for MR imaging-guided chemotherapy of glioma. The nanogel exhibits dual pH and redox-responsive release profiles, enhancing chemotherapy/CDT efficacy.

ACS NANO (2021)

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Article Engineering, Biomedical

A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy

Jian Chen et al.

Summary: The carrier-free Fe(III)-ART nanoparticles, triggered by intracellular GSH, release ART and Fe3+, catalyzing the endoperoxide of ART to generate C-centered free radicals. This application demonstrates superior anticancer efficacy and contributes to activatable MRI-guided chemodynamic therapy.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Intelligent MoS2-CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy/ chemodynamic therapy/ immunotherapy

Fan Jiang et al.

Summary: The MoS2-CuO nanoplatform designed in this study integrates multimodal imaging and therapeutic functions for cancer treatment. It is capable of enhancing antitumor efficacy through a combination of photothermal therapy, chemodynamic therapy, and immunotherapy, while also generating strong antitumor immune responses for effectively eliminating primary and metastatic tumors.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Biomedicine Meets Fenton Chemistry

Zhongmin Tang et al.

Summary: This review provides a comprehensive overview of the importance and representative applications of Fenton chemistry in the field of biomedicine, as well as future directions for development, which is essential for further advancement in this field.

CHEMICAL REVIEWS (2021)

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Article Engineering, Environmental

Remodeling endogenous H2S microenvironment in colon cancer to enhance chemodynamic therapy

Donglin Liu et al.

Summary: Chemodynamic therapy (CDT) is a minimally invasive treatment with high selectivity and promising clinical application, but it lacks effectiveness in inhibiting the growth of colon cancer due to the strongly reducing tumor microenvironment. A new strategy utilizing CuFe2O4 nanoparticles to deplete endogenous H2S and enhance CDT has been proposed, showing significant synergistic effects on improving the performance of CDT for colon cancer.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Chemoreactive Nanotherapeutics by Metal Peroxide Based Nanomedicine

Hui Hu et al.

Summary: This paper summarizes the representative examples of metal peroxides in chemoreactive nanomedicine, discusses their applications in various disease treatments and the mechanisms for enhancing therapeutic efficacy, and explores their biological effects and biosafety. Finally, it delves into the existing gap between fundamental research and clinical translation of metal peroxide-based nanotherapeutic technologies.

ADVANCED SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Nanomaterial-Based Nanoplatforms for Chemodynamic Cancer Therapy

Shu-Lan Li et al.

Summary: Chemodynamic therapy (CDT) uses endogenous chemical energy in the tumor microenvironment for treatment, converting hydrogen peroxide into reactive oxygen species for oncotherapy. However, limitations in the tumor microenvironment hinder CDT efficacy, and the development of nanotechnology offers potential solutions to improve CDT efficiency.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

An Acidity-Unlocked Magnetic Nanoplatform Enables Self-Boosting ROS Generation through Upregulation of Lactate for Imaging-Guided Highly Specific Chemodynamic Therapy

Linan Shi et al.

Summary: A novel nanoplatform was developed in this study, which can achieve high-efficient tumor-specific catalytic anticancer treatment in acidic tumor microenvironments through a cyclic amplification strategy, leading to enhanced Fenton-like reaction. Ultimately, this smart nanoplatform enables self-boosting generation of reactive oxygen species (ROS), inducing strong intracellular oxidative stress, and resulting in substantial anticancer outcomes in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Engineering, Environmental

Tumor microenvironment-triggered MoS2@GA-Fe nanoreactor: A self-rolling enhanced chemodynamic therapy and hydrogen sulfide treatment for hepatocellular carcinoma

Huili Zheng et al.

Summary: In this study, MoS2@GA-Fe nanosheets with high Fe(III) loading were prepared and demonstrated to function as a Fenton Nanoreactor in the tumor microenvironment. The reactive hydroxyl radicals were generated during the Fenton reaction, leading to enhanced antitumor efficiency and biosafety, showing promising potential for tumor therapy.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Biomedical

Ultrasensitive Chemodynamic Therapy: Bimetallic Peroxide Triggers High pH-Activated, Synergistic Effect/H2O2 Self-Supply-Mediated Cascade Fenton Chemistry

Hao Zhou et al.

Summary: This paper introduces the fabrication of Fenton-type bimetallic peroxides for ultrasensitive chemodynamic therapy with high pH-activated, synergistic effect/H2O2 self-supply-mediated cascade Fenton chemistry. These bimetallic peroxides exhibit high-efficiency tumor catalytic therapy with negligible side effects in vivo, and will likely drive interest in developing smart high-efficiency nanoplatforms for cancer theranostics.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation

Deblin Jana et al.

Summary: The study presents an ultrasmall trimetallic alloy nanozyme that exhibits therapeutic effects at neutral pH, with accelerated tumor cell apoptosis through synergistic photothermal and ultrasound effects. This provides a strategy for enhancing the efficiency of chemodynamic therapy targeting tumors.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Breaking the Redox Homeostasis: an Albumin-Based Multifunctional Nanoagent for GSH Depletion-Assisted Chemo-/Chemodynamic Combination Therapy

Kaicheng Liang et al.

Summary: By developing novel nanoagents that can disrupt redox homeostasis for tumor therapy, a multifunctional albumin-based nanoagent was successfully developed in this study. By depleting glutathione (GSH) to assist chemotherapy and chemodynamic therapy, this method increases oxidative stress and enhances therapeutic effects.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Materials Science, Biomaterials

Multifunctional FeS2@SRF@BSA nanoplatform for chemo-combined photothermal enhanced photodynamic/chemodynamic combination therapy

Miao Feng et al.

Summary: A FeS2@SRF@BSA nanoplatform was developed for combination chemo-photothermal therapy, enhanced photodynamic therapy, and chemodynamic therapy. The nanoplatform showed good biocompatibility, stability, and therapeutic efficacy, making it a promising multifunctional therapeutic agent for cancer treatment in the future.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Physical

Cu-MOF chemodynamic nanoplatform via modulating glutathione and H2O2 in tumor microenvironment for amplified cancer therapy

Hailong Tian et al.

Summary: The study developed a novel Cu-MOF-199 nanoplatform integrating vitamin K3, which modulates endogenous H2O2 and GSH levels to amplify the effect of chemodynamic therapy, effectively inhibiting tumor growth with minimal side effects in vivo.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Review Chemistry, Analytical

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

Dong Li et al.

Summary: Recently, activatable NIR-II fluorescent probes have shown to have specific targeting to biological tissues, providing higher imaging signal-to-background ratio and lower detection limit. Utilizing disease-associated endogenous stimuli to activate NIR-II probes is significant for achieving switchable fluorescent signals for specific deep bioimaging applications. Challenges and perspectives of activatable NIR-II fluorescent probes are also discussed in this review.

BIOSENSORS-BASEL (2021)

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Review Engineering, Biomedical

Transitional Metal-Based Noncatalytic Medicine for Tumor Therapy

Wencheng Wu et al.

Summary: Nanocatalytic medicine is a promising strategy for cancer therapeutics that generates toxic agents within tumors through catalytic reactions. Transitional metal-based nanocatalytic medicines show significant catalytic activity and clinical potential, but face obstacles and challenges in design and clinical application.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Metal-Organic Framework-Based Nanoagents for Effective Tumor Therapy by Dual Dynamics-Amplified Oxidative Stress

Jiajie Chen et al.

Summary: This study develops a nanoscale iron-based metal-organic framework for enhanced ROS production within tumors and amplified oxidative damage through chemodynamic and photodynamic effects, providing a more effective therapeutic outcome. In vitro results demonstrate acid-responsive CDT and effective PDT, with synergistic therapeutic effects achieved by the nanoagents.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

H2O2 Self-Supplying and GSH-Depleting Nanoplatform for Chemodynamic Therapy Synergetic Photothermal/Chemotherapy

Zhimei Xiao et al.

Summary: This study proposed an intelligent nanoplatform that induces the depletion of GSH and self-supply of H2O2 in tumor cells to enhance the efficacy of chemodynamic therapy (CDT). Through various mechanisms, the integration of chemotherapy, photothermal therapy, and CDT was realized.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Mixed-Metal MOF-Derived Hollow Porous Nanocomposite for Trimodality Imaging Guided Reactive Oxygen Species-Augmented Synergistic Therapy

Yue Cheng et al.

Summary: This study proposes a trimodality therapy using a mixed-metal MOF composite for synergistic photothermal therapy, photodynamic therapy, and chemodynamic therapy. The composite with hollow structures efficiently integrates multiple functions to enhance treatment efficacy.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A Robust ROS Generation Strategy for Enhanced Chemodynamic/Photodynamic Therapy via H2O2/O2 Self-Supply and Ca2+ Overloading

Jie Shen et al.

Summary: The smart polyethylene glycol (PEG)-ylated nanosystem CaO2@ZIF-Fe/Ce6@PEG (CaZFCP) is designed to supply H2O2/O-2 and cause Ca2+ overloading in tumor cells, enhancing the efficacy of chemodynamic therapy (CDT) and photodynamic therapy (PDT) simultaneously. The CaZFCP releases CaO2 nanoparticles, Fe2+, and photosensitizer Chlorin e6 (Ce6) in the weakly acidic tumor microenvironment, alleviating the deficiency of endogenous H2O2 and hypoxia in the tumor area, leading to enhanced production of hydroxyl radicals and singlet oxygen for improved CDT and PDT. Additionally, the Ca2+ overloading induced by CaO2 decomposition amplifies intracellular oxidative stress, resulting in mitochondrial dysfunction and further enhancing the efficacy of combined CDT/PDT. The in vitro and in vivo experimental results confirm the excellent tumor inhibition effect of CaZFCP, providing a simple paradigm for ROS-involved cancer therapies.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Oncology

Reactive oxygen species in cancer: Current findings and future directions

Hajime Nakamura et al.

Summary: Reactive oxygen species (ROS) play a crucial role in cancer, with low to moderate levels activating cell functions and high levels causing cell death. Therapies manipulating ROS levels show promise for cancer treatment, offering new opportunities for therapeutic strategies.

CANCER SCIENCE (2021)

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Article Engineering, Environmental

Biomineralized DNA nanospheres by metal organic framework for enhanced chemodynamic therapy

Peipei Wang et al.

Summary: In this study, metal organic framework (MOF)-biomineralized DNA nanospheres were developed as chemodynamic therapy (CDT) agents with tumor-activable cascade reactions for boosting intracellular H2O2 concentration, achieving remarkable antitumor outcome. The CDT agent utilizes tumor acid-induced dissociation to release Fe2+/Fe3+ for Fenton reaction and GOx for catalyzing glucose into H2O2, synergistically elevating ROS level in tumor cells to induce ferroptosis. This strategy provides a promising approach for developing CDT agents with improved therapeutic efficacy.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development

Dong Li et al.

Summary: Sonodynamic therapy (SDT) is a novel noninvasive therapeutic approach that combines low-intensity ultrasound with sonosensitizers. Compared to phototherapy, SDT offers advantages such as deeper tissue penetration, high accuracy, and reduced side effects. The use of organic sonosensitizers is crucial for therapeutic efficacy, and nanotechnology holds potential for overcoming obstacles and fostering innovation in this field.

SMALL (2021)

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Article Multidisciplinary Sciences

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

Xing Qin et al.

Summary: This study demonstrates a peroxisome-inspired approach for tumor therapy by incorporating lactate oxidase and catalase into nanoparticles. This method effectively inhibits tumor growth by regulating intracellular ROS levels.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

Shawn C. Chafe et al.

Summary: The study identified a redox homeostasis network involving the iron-sulfur cluster enzyme NFS1 in the survival mechanisms governed by the tumor hypoxia-induced pH regulator CAIX. Targeting CAIX while depleting NFS1 or blocking cyst(e)ine availability enhanced ferroptosis and inhibited tumor growth significantly. Altering intracellular pH and iron homeostasis through inhibiting CAIX activity may lead to the development of innovative therapeutic strategies for solid tumors to overcome hypoxia- and acidosis-mediated tumor progression and therapeutic resistance.

SCIENCE ADVANCES (2021)

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Article Chemistry, Physical

Macrophage-hitchhiking supramolecular aggregates of CuS nanoparticles for enhanced tumor deposition and photothermal therapy

Junyan Li et al.

Summary: In this design, CuS nanoparticles were intracellularly self-assembled into large supramolecular aggregates via host-guest interactions, significantly inhibiting efflux during macrophage-hitchhiking delivery. This strategy enhanced deposition of CuS NPs in tumor tissue, improving photothermal therapy efficacy.

NANOSCALE HORIZONS (2021)

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Review Chemistry, Multidisciplinary

Advances in photothermal nanomaterials for biomedical, environmental and energy applications

Si Yin Tee et al.

Summary: Materials exhibiting photothermal effect have attracted significant research interest for their ability to efficiently convert light into heat. Recent advancements in nano-enabled materials, such as plasmonic metals and semiconductors, have led to improved photothermal performance. Strategic engineering of nanostructured size, shape, composition, and bandgap is crucial for enhancing light harvesting and photothermal conversion capabilities of these materials.

NANOSCALE (2021)

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Article Materials Science, Biomaterials

Synergistically enhanced multienzyme catalytic nanoconjugates for efficient cancer therapy

Sheng-Yan Yin et al.

Summary: The study presents a robust cascade biomimetic nanoplatform integrating chemiluminescence-induced photodynamic therapy, Fenton reaction-based chemodynamic therapy, and glucose oxidase-mediated starvation therapy to enhance cancer treatment synergistically. The nanoplatform shows excellent anti-tumor performance in both in vitro and in vivo studies, broadening the pathway to fight against cancer through effective cascade catalysis.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

Cascade catalytic nanoplatform constructed by laterally-functionalized pillar[5]arenes for antibacterial chemodynamic therapy

Fei Li et al.

Summary: Chemodynamic therapy (CDT) is a promising approach for combating bacterial infections by converting H2O2 into highly toxic OH, but developing safe and effective CDT strategies is challenging. The designed cascade catalytic nanoplatform can effectively catalyze glucose to produce H2O2, trigger Fenton reaction, and achieve antibacterial CDT, with little to no cytotoxicity towards mammalian cells.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Multidisciplinary

A pH-responsive ultrathin Cu-based nanoplatform for specific photothermal and chemodynamic synergistic therapy

Tingting Hu et al.

Summary: This study has developed a novel tumor therapy nanoplatform by integrating acid-enhanced photothermal therapy and pH-responsive chemodynamic therapy, which almost eliminates tumor tissue in vivo with low-dose drug injection.

CHEMICAL SCIENCE (2021)

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Article Medicine, Research & Experimental

Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy

Lina Sun et al.

Summary: The developed Si-Pt NCs exhibit strong sonodynamic therapy and chemodynamic therapy effects, with a higher therapeutic efficacy. Taking advantage of the mesoporous structure, the mild photothermal effect further enhances the combined cancer therapy of SDT and CDT provided by Si-Pt NCs.

THERANOSTICS (2021)

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Article Nanoscience & Nanotechnology

Engineering H2O2 Self-Supplying Nanotheranostic Platform for Targeted and Imaging-Guided Chemodynamic Therapy

Yajing Han et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Hollow Porous Carbon Coated FeS2-Based Nanocatalysts for Multimodal Imaging-Guided Photothermal, Starvation, and Triple-Enhanced Chemodynamic Therapy of Cancer

Fan Wu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Chemistry, Multidisciplinary

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Binbin Ding et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Biodegradable Nanoprodrugs: Delivering ROS to Cancer Cells for Molecular Dynamic Therapy

Zhong-min Tang et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Metal-Polyphenol-Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

Zhigang Ren et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Environmental

Platelet membrane biomimetic bufalin-loaded hollow MnO2 nanoparticles for MRI-guided chemo-chemodynamic combined therapy of cancer

Haijun Wang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Multidisciplinary

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

Yanjuan Sang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Nanoscience & Nanotechnology

Fe3O4 Mesocrystals with Distinctive Magnetothermal and Nanoenzyme Activity Enabling Self-Reinforcing Synergistic Cancer Therapy

Wenxian Du et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Integration of Fe3O4 with Bi2S3 for Multi-Modality Tumor Theranostics

Keyi Luo et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Analytical

Biodegradable Metal-Organic Frameworks Power DNAzyme for in Vivo Temporal-Spatial Control Fluorescence Imaging of Aberrant MicroRNA and Hypoxic Tumor

Xiangdan Meng et al.

ANALYTICAL CHEMISTRY (2020)

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Article Engineering, Environmental

Tumor environment responsive degradable CuS@mSiO2@MnO2/DOX for MRI guided synergistic chemo-photothermal therapy and chemodynamic therapy

Minyi Zhang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Medicinal

A non-aggregated silicon(IV) phthalocyanine-lactose conjugate for photodynamic therapy

Dong Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)

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Article Chemistry, Multidisciplinary

A Nanomedicine Fabricated from Gold Nanoparticles-Decorated Metal-Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy

Yuan Ding et al.

ADVANCED SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing

Fei Gao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Engineering, Biomedical

Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy

Yuanlin Wang et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics

Huican Duan et al.

BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Metal-Polymer Hybrid Biomimetic System for use in the Chemodynamic-Enhanced Photothermal Therapy of Cancers

Lingdan Kong et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

Biodegradable Fe-Doped Vanadium Disulfide Theranostic Nanosheets for Enhanced Sonodynamic/Chemodynamic Therapy

Huali Lei et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Chemistry, Multidisciplinary

Recent progress of chemodynamic therapy-induced combination cancer therapy

Xianwen Wang et al.

NANO TODAY (2020)

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Article Physics, Applied

V-TiO2 nanospindles with regulating tumor microenvironment performance for enhanced sonodynamic cancer therapy

Xianwen Wang et al.

APPLIED PHYSICS REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy

Shang Bai et al.

ACS NANO (2020)

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Article Materials Science, Biomaterials

Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics

Qian Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Nanoscience & Nanotechnology

Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy

Qian Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Specific Generation of Singlet Oxygen through the Russell Mechanism in Hypoxic Tumors and GSH Depletion by Cu-TCPP Nanosheets for Cancer Therapy

Chao Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Engineering, Biomedical

Ultrasmall Cu2-XS nanodots as photothermal-enhanced Fenton nanocatalysts for synergistic tumor therapy at NIR-II biowindow

Ruizhi Hu et al.

BIOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy

Li-Sen Lin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Chemistry, Multidisciplinary

被撤回的出版物: Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy (Retracted article. See vol. 9, pg. 755, 2023)

Kaiyuan Ni et al.

CHEM (2019)

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Article Nanoscience & Nanotechnology

Manganese-Based Nanoplatform As Metal Ion-Enhanced ROS Generator for Combined Chemodynamic/Photodynamic Therapy

Peng Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Nanoscience & Nanotechnology

Construction of Urokinase-Type Plasminogen Activator Receptor-Targeted Heterostructures for Efficient Photothermal Chemotherapy against Cervical Cancer To Achieve Simultaneous Anticancer and Antiangiogenesis

Xiaoli Hu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Copper(I) Phosphide Nanocrystals for In Situ Self-Generation Magnetic Resonance Imaging-Guided Photothermal-Enhanced Chemodynamic Synergetic Therapy Resisting Deep-Seated Tumor

Yang Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Zinc(II)-Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy

Chengchao Chu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Engineering, Environmental

Glutathione and H2O2 consumption promoted photodynamic and chemotherapy based on biodegradable MnO2-Pt@Au25 nanosheets

Huiting Bi et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Article Oncology

Inhibition of hydrogen sulfide synthesis reverses acquired resistance to 5-FU through miR-215-5p-EREG/TYMS axis in colon cancer cells

Shanwen Chen et al.

CANCER LETTERS (2019)

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Article Chemistry, Multidisciplinary

Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione AND H2O2 Sequentially Triggered Chemodynamic Therapy

Baojin Ma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Chemistry, Multidisciplinary

Programming Drug Delivery Kinetics for Active Burst Release with DNA Toehold Switches

Mingshu Xiao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Chemistry, Multidisciplinary

Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy

Sheng Wang et al.

ADVANCED SCIENCE (2019)

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Article Chemistry, Physical

Magnetic Squashing of Circulating Tumor Cells on Plasmonic Substrates for Ultrasensitive NIR Fluorescence Detection

Ru Zhang et al.

SMALL METHODS (2019)

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Article Chemistry, Multidisciplinary

Reduction of CO2 with H2S in a simulated deep-sea hydrothermal vent system

Runtian He et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Medicine, Research & Experimental

Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy

Li-Sen Lin et al.

THERANOSTICS (2019)

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Article Materials Science, Biomaterials

Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with a high signal-to-noise ratio

Huixiang Yan et al.

BIOMATERIALS SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Tumor-selective catalytic nanosystem for activatable theranostics

Lu-Ying Duan et al.

CHEMICAL COMMUNICATIONS (2018)

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Review Chemistry, Multidisciplinary

Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

Lian-Hua Fu et al.

CHEMICAL SOCIETY REVIEWS (2018)

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Article Chemistry, Multidisciplinary

Magnetic Targeting, Tumor Microenvironment-Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation

Lili Feng et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion

Lu Zhang et al.

NANO LETTERS (2018)

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Article Multidisciplinary Sciences

A RNA producing DNA hydrogel as a platform for a high performance RNA interference system

Jaejung Song et al.

NATURE COMMUNICATIONS (2018)

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Review Oncology

Prospects for combining targeted and conventional cancer therapy with immunotherapy

Philip Gotwals et al.

NATURE REVIEWS CANCER (2017)

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Article Chemistry, Analytical

Fluorescent nitrogen and sulfur co-doped carbon dots from casein and their applications for sensitive detection of Hg2+ and biothiols and cellular imaging

Shouming Xu et al.

ANALYTICA CHIMICA ACTA (2017)

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Article Chemistry, Multidisciplinary

Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome

Wei-Peng Li et al.

ACS NANO (2016)

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Article Engineering, Biomedical

Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T1-MRI contrast agents and drug delivery carriers

Xiaowei Li et al.

ACTA BIOMATERIALIA (2016)

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Article Chemistry, Multidisciplinary

Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Chen Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Oncology

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors

Xiumei Huang et al.

CANCER CELL (2016)

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Article Chemistry, Multidisciplinary

Polymeric micellar nanoplatforms for Fenton reaction as a new class of antibacterial agents

Seong-Cheol Park et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

Hydrophobic Cysteine Poly(disulfide)-based Redox-Hypersensitive Nanoparticle Platform for Cancer Theranostics

Jun Wu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

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Article Biophysics

Carbon dot cluster as an efficient off-on fluorescent probe to detect Au(III) and glutathione

Jiangjiang Gu et al.

BIOSENSORS & BIOELECTRONICS (2015)

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Article Chemistry, Multidisciplinary

Self-assembly of DNA Nanohydrogels with Controllable Size and Stimuli-Responsive Property for Targeted Gene Regulation Therapy

Juan Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Engineering, Electrical & Electronic

Tinospora cordifolia mediated facile green synthesis of cupric oxide nanoparticles and their photocatalytic, antioxidant and antibacterial properties

Udayabhanu et al.

MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING (2015)

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Article Chemistry, Multidisciplinary

Aqueous synthesis of PEGylated copper sulfide nanoparticles for photoacoustic imaging of tumors

Ke Ding et al.

NANOSCALE (2015)

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Review Oncology

A brief history of cancer: Age-old milestones underlying our current knowledge database

Guy B. Faguet

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Chemistry, Multidisciplinary

ROS-triggered and regenerating anticancer nanosystem: An effective strategy to subdue tumor's multidrug resistance

Zhigui Su et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Review Engineering, Environmental

Review of iron-free Fenton-like systems for activating H2O2 in advanced oxidation processes

Alok D. Bokare et al.

JOURNAL OF HAZARDOUS MATERIALS (2014)

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Article Chemistry, Multidisciplinary

Surface Plasmon Resonance Enhanced Light Absorption and Photothermal Therapy in the Second Near-Infrared Window

Xianguang Ding et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Article Oncology

Synergy between chemotherapeutic agents and CTLA-4 blockade in preclinical tumor models

Maria Jure-Kunkel et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)

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Review Chemistry, Multidisciplinary

On the Synergetic Catalytic Effect in Heterogeneous Nanocomposite Catalysts

Jianlin Shi

CHEMICAL REVIEWS (2013)

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Article Biophysics

The green synthesis, characterization and evaluation of the biological activities of silver nanoparticles synthesized from Iresine herbstii leaf aqueous extracts

C. Dipankar et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2012)

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Article Engineering, Environmental

Magnetic Nanoscaled Fe3O4/CeO2 Composite as an Efficient Fenton-Like Heterogeneous Catalyst for Degradation of 4-Chlorophenol

Lejin Xu et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)

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Article Neurosciences

Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity

Hyung-Jin Kim et al.

JOURNAL OF NEUROSCIENCE (2010)

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Review Chemistry, Medicinal

The Fe2+-mediated decomposotion, PfATP6 binding, and antimalarial activities of artemisone and other arteminisins:: The unlikehood of C-centered radicals as bioactive intermediates

Richard K. Haynes et al.

CHEMMEDCHEM (2007)

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Article Nanoscience & Nanotechnology

Intrinsic peroxidase-like activity of ferromagnetic nanoparticles

Lizeng Gao et al.

NATURE NANOTECHNOLOGY (2007)

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Article Chemistry, Multidisciplinary

Enhanced anticancer efficacy of α-tocopheryl succinate by conjugation with polyethylene glycol

HJ Youk et al.

JOURNAL OF CONTROLLED RELEASE (2005)

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Article Agriculture, Dairy & Animal Science

Effect of α-tocopherol and tocopherol succinate on lipid peroxidation in equine spermatozoa

J Almeida et al.

ANIMAL REPRODUCTION SCIENCE (2005)

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Review Biochemistry & Molecular Biology

Hydrogen peroxide in the human body

B Halliwell et al.

FEBS LETTERS (2000)

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