☆ 4.3 Article

Dibromo- and Dichlorotriphenylphosphino N-Acyclic Carbene Complexes of Platinum(II)-Synthesis and Cytotoxicity

INORGANICS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Medicinal

Reaction Behavior of [1,3-Diethyl-4,5-diphenyl-1H-imidazol-2-ylidene] Containing Gold(I/III) Complexes against Ingredients of the Cell Culture Medium and the Meaning on the Potential Use for Cancer Eradication Therapy

Paul Kapitza et al.

Summary: The reactivities of gold complexes with different ligands were analyzed in cell culture medium. Complexes 6 and 7 showed significant reactions, while interactions with non-thiol containing amino acids were not detected. Complex 8 exhibited strong stability and contributed to the biological effects of complex 7. The gold(III) species were reduced by GSH and showed promising activity against drug-resistant tumors.

JOURNAL OF MEDICINAL CHEMISTRY (2023)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Dibromo-Isonitrile and N-acyclic Carbene Complexes of Platinum(II): Synthesis and Reactivity

Anna Farasat et al.

Summary: A series of dibromo-N-acyclic (NAC) carbene complexes of platinum(II) were synthesized using a previously optimized protocol for analogous chlorinated compounds, starting from trans-[Pt(mu-Br)Br(PPh3)](2). The synthesis involved ring opening of the dinuclear precursor using suitable isonitrile ligands, followed by addition of N,N-diethylamine to the resulting products. Separate investigations were conducted for the two reactions with a focus on the differences between brominated and chlorinated systems.

INORGANICS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

trans-Dichloro(triphenylarsino)(N,N-dialkylamino)platinum(II) Complexes: In Search of New Scaffolds to Circumvent Cisplatin Resistance

Mariafrancesca Hyeraci et al.

Summary: Resistance to cisplatin limits its usefulness as an anticancer drug. This study describes the synthesis and characterization of two new platinum complexes and demonstrates their potential in overcoming cisplatin resistance in cancer cells. The complexes exhibited poor ability to platinate DNA but showed significant intracellular accumulation. Mechanistic studies revealed their ability to inhibit DNA relaxation and activate the apoptotic pathway. Comparison with related complexes provides insights into the resistance phenotype.

MOLECULES (2022)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Addition of aliphatic, secondary amines to coordinated isonitriles. N-acyclic carbene (NAC) platinum(II) complexes from trans-[Pt(μ-Cl)Cl(PPh3)]2

Anna Farasat et al.

Summary: Isocyanide ligands react with transition metal complexes to form corresponding complexes, and react with amines to form non-cyclic carbene addition products.

INORGANICA CHIMICA ACTA (2022)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

An overview of anticancer platinum N-heterocyclic carbene complexes

Sai Zhao et al.

Summary: NHCs have been introduced as a new platform for the development of anticancer metal complexes, with platinum NHC complexes showing comparable activities to cisplatin and exhibiting different mechanisms of action, including the induction of biochemical hallmarks of immunogenic cell death (ICD) as a type II ICD inducer. These features make them promising candidates in the field of anticancer research.

COORDINATION CHEMISTRY REVIEWS (2021)

添加到收藏夹

Article Chemistry, Medicinal

New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells

Mariafrancesca Hyeraci et al.

Summary: The new platinum complexes show significant antiproliferative effects on resistant ovarian carcinoma cells, demonstrating notable intracellular accumulation and the ability to interact with different intracellular targets. The mechanism of action involves interaction with DNA, collapse of mitochondrial transmembrane potential, and impairment of intracellular redox state, as well as selectivity towards selenocysteine of thioredoxin reductase.

CHEMMEDCHEM (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cytotoxicity and DNA interaction in a series of aryl terminated iminopyridine Pt(II) complexes

Riccardo Bondi et al.

Summary: The newly synthesized platinum(II) iminopyridine complexes exhibit good solubility and stability, with good interactions with DNA and significant antiproliferative activity on ovarian carcinoma cells. Complex 13 shows the ability to overcome cisplatin resistance and forms a dual geometry molecular complex with DNA, with hindered interstrand cross-links compared to cisplatin. The interactions with DNA are discussed in relation to the observed cell effects.

JOURNAL OF INORGANIC BIOCHEMISTRY (2021)

添加到收藏夹

Review Oncology

The rediscovery of platinum-based cancer therapy

Sven Rottenberg et al.

Summary: Platinum chemotherapy agents continue to be widely used in cancer treatment, with recent insights into DNA repair mechanisms providing valuable explanations for their success. The understanding of defective DNA repair in many cancers sheds new light on secondary drug resistance mechanisms.

NATURE REVIEWS CANCER (2021)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

N-Heterocyclic Carbene Platinum Complexes: A Big Step Forward for Effective Antitumor Compounds

Stephane Bellemin-Laponnaz

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

DNA interaction of a fluorescent, cytotoxic pyridinimino platinum(II) complex

Riccardo Bondi et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Medicinal

Platinum(II) Complexes Bearing Triphenylphosphine and Chelating Oximes: Antiproliferative Effect and Biological Profile in Resistant Cells

Mariafrancesca Hyeraci et al.

CHEMMEDCHEM (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Reactions of cisplatin and cis-[PtI2(NH3)2] with molecular models of relevant protein sidechains: A comparative analysis

Iogann Tolbatov et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

N-Heterocyclic Carbene Gold(I) Complexes: Mechanism of the Ligand Scrambling Reaction and Their Oxidation to Gold(III) in Aqueous Solutions

Sina K. Goetzfried et al.

INORGANIC CHEMISTRY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitochondria-Targeting Anticancer Metal Complexes

Andrea Erxleben

CURRENT MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

A Sound Sequence to Triphenylphosphino Dibromoplatinum(II) Complexes - Solvothermal Preparation of trans-[PtBr(μ-Br)(PPh3)]2

David Fioco et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Synthesis and Reactivity of Cytotoxic Platinum(II) Complexes of Bidentate Oximes - A Step towards the Functionalization of Bioactive Complexes

Daniela Belli Dell'Amico et al.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2018)

添加到收藏夹

Review Chemistry, Medicinal

New insights in Au-NHCs complexes as anticancer agents

Marina Porchia et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Oxaliplatin reacts with DMSO only in the presence of water

Hristo P. Varbanov et al.

DALTON TRANSACTIONS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles

Tiziano Marzo et al.

BIOMETALS (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

New trans dichloro (triphenylphosphine)platinum(II) complexes containing N-(butyl),N-(arylmethyl)amino ligands: Synthesis, cytotoxicity and mechanism of action

Lisa Dalla Via et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Review Oncology

Platinum-based drugs: past, present and future

Shahana Dilruba et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

Timothy C. Johnstone et al.

CHEMICAL REVIEWS (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Palladium complexes: new candidates for anti-cancer drugs

Ehsan Zareian Jahromi et al.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Oncology

Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes

Matthew D. Hall et al.

CANCER RESEARCH (2014)

添加到收藏夹

Review Pharmacology & Pharmacy

Cisplatin in cancer therapy: Molecular mechanisms of action

Shaloam Dasari et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum-bisphosphonate complexes in the treatment of bone tumors: A mini-review

Michele Iafisco et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular mechanisms of cisplatin resistance

L. Galluzzi et al.

ONCOGENE (2012)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Synthesis, characterization and tumor cell growth inhibition of new trans platinum complexes with phosphane derivatives

A. G. Quiroga et al.

POLYHEDRON (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

Luminescent cyclometalated platinum(II) complexes containing N-heterocyclic carbene ligands with potent in vitro and in vivo anti-cancer properties accumulate in cytoplasmic structures of cancer cells

Raymond Wai-Yin Sun et al.

CHEMICAL SCIENCE (2011)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Targeting mitochondria for cancer therapy

Simone Fulda et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

添加到收藏夹

Review Pharmacology & Pharmacy

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism

Divya Pathania et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Optimization of cisplatin for the treatment of hormone dependent tumoral diseases Part 1: Use of steroidal ligands

Ronald Gust et al.

COORDINATION CHEMISTRY REVIEWS (2009)

添加到收藏夹

Editorial Material Pharmacology & Pharmacy

Satraplatin: leading the new generation of oral platinum agents

Ashish Bhargava et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

Carbohydrate-Metal Complexes and their Potential as Anticancer Agents

Christian G. Hartinger et al.

CURRENT MEDICINAL CHEMISTRY (2008)

添加到收藏夹

Review Oncology

The resurgence of platinum-based cancer chemotherapy

Lloyd Kelland

NATURE REVIEWS CANCER (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators

Sharon Kemp et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2007)

添加到收藏夹

Review Oncology

Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review

Britta Stordal et al.

CANCER TREATMENT REVIEWS (2007)

添加到收藏夹

Article Chemistry, Medicinal

New trans-platinum drugs with phosphines and amines as carrier ligands induce apoptosis in tumor cells resistant to cisplatin

Francisco J. Ramos-Lima et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Platinum complexes with imino ethers or cyclic ligands mimicking imino ethers: synthesis, in vitro antitumour activity, and DNA interaction properties

FP Intini et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2004)

添加到收藏夹

Article Oncology

FDA drug approval summaries: Oxaliplatin

A Ibrahim et al.

ONCOLOGIST (2004)

添加到收藏夹

Review Oncology

Mitochondrion as a novel target of anticancer chemotherapy

P Costantini et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.