期刊
INORGANICS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/inorganics11090365
关键词
Platinum(II) bromo- and chlorocomplexes; carbene ligands; triphenylphosphine; chloro-bromo metathesis; cytotoxicity
This study synthesized a series of new N-acyclic carbene and isonitrile complexes of platinum(II). Among them, NAC derivatives showed a moderate cytotoxic effect on MSTO-211H cells.
Some new dichloro- and dibromotriphenylphosphino isonitrile and N-acyclic (NAC) carbene complexes of platinum(II) were synthesized, starting from suitable dinuclear precursors. The reaction of cyclohexylisonitrile with trans-[Pt(mu-X)X(PPh3)]2, followed by the addition of N,N-diethylamine afforded the corresponding N-acyclic carbene (NAC)derivatives cis-[PtX2(PPh3)(NAC)] in 61-64% isolated yield. The cis geometry was attributed based on the comparison with known structures. The stability of the complexes in pure DMSO, DMSO/H2O, and DMSO/NaClaq mixtures was evaluated. While pure DMSO, as well as DMSO/H2O, did not affect the nature of either dichloro- or dibromo-compounds, dibromo derivatives were not stable in the presence of chloride ions. Since a high concentration of chloride ions is essential to perform in vitro cell assays, only dichlorocomplexes were tested as cytotoxic agents against HepG2 and human tumor cells. Among the tested complexes, NAC derivatives showed a moderate effect on MSTO-211H.
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