4.4 Article

GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Impairing Tumor Metabolic Plasticity via a Stable Metal-Phenolic-Based Polymeric Nanomedicine to Suppress Colorectal Cancer

Xiaoling Li et al.

Summary: Targeting the metabolic vulnerability of tumor cells is a promising anticancer strategy. Researchers have developed a nanomedicine called pOEG-b-D-SH@NP, which encapsulates maleimide-modified doxorubicin (Mal-DOX), to improve overall delivery efficiency and inhibit tumor metabolism through multiple pathways. The nanomedicine effectively depletes energy in colorectal cancer cells and shifts cell death from apoptosis to necroptosis. It also inhibits cellular oxidative phosphorylation and glycolysis, suppressing cancer growth in mouse models.

ADVANCED MATERIALS (2023)

Article Engineering, Biomedical

Boosting Doxorubicin-Induced Mitochondria Apoptosis for the Monodrug-Mediated Combination of Chemotherapy and Chemodynamic Therapy

Tao Liu et al.

Summary: Doxorubicin can induce mitochondrial apoptosis by generating reactive oxygen radicals (ROS), and this newly identified mechanism can enhance the antitumor effect. Using one-pot nanoconstruction (HEBD) can amplify the effect of Doxorubicin therapy, similar to the combination of chemodynamic therapy (CDT) and chemotherapy. This strategy can improve the antitumor effect, extend the lifespan of mice, and reduce the risks of cardiotoxicity and metastasis.

ADVANCED HEALTHCARE MATERIALS (2023)

Article Chemistry, Multidisciplinary

Fibronectin-Coated Metal-Phenolic Networks for Cooperative Tumor Chemo-/Chemodynamic/Immune Therapy via Enhanced Ferroptosis-Mediated Immunogenic Cell Death

Yao Xu et al.

Summary: The development of a multifunctional theranostic nanoplatform based on doxorubicin-loaded tannic acid-iron networks is described. The platform shows excellent stability, strong targeting ability, and provides the advantages of cooperative immune therapy through iron-based chemodynamic therapy and doxorubicin chemotherapy.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy

Kewei Wang et al.

Summary: In this study, a clustered nanosystem was designed to overcome hypoxic resistance in tumors and enhance chemoimmunotherapy. This system utilized tumor acidity-responsive groups and bioorthogonal click chemistry to form large-sized aggregates in tumor tissue, which then slowly dissociated into ultrasmall nanoparticles for enhanced drug delivery. This system not only addressed hypoxia-induced chemoresistance and enhanced antitumor immune responses but also provided a general drug delivery strategy for improved tumor accumulation and penetration.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Engineering Multienzyme-Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity

Liang Zhang et al.

Summary: A series of multienzyme-mimicking covalent organic frameworks (COFs) have been engineered to induce pyroptosis and remodel the tumor microenvironment, boosting cancer immunotherapy.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Intelligent Gold Nanoparticles with Oncogenic MicroRNA-Dependent Activities to Manipulate Tumorigenic Environments for Synergistic Tumor Therapy

Xiangdong Wang et al.

Summary: This study utilizes spherical nucleic acids (SNAs) to effectively utilize and manipulate oncogenic microRNAs for tumor therapy. SNAs capture overexpressed miR-21/miR-155 and exert their effects through gene therapy and chemotherapy, while also achieving photothermal therapy and enhancing tumor treatment outcomes.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Copper-Based Metal-Organic Framework Overcomes CancerChemoresistance through Systemically Disrupting DynamicallyBalanced Cellular Redox Homeostasis

Jia Liu et al.

Summary: This study presents a copper/catechol-based metal-organic framework that disrupts the redox homeostasis in drug-resistant cancer cells, leading to increased cellular oxidative stress and selective cytotoxicity. The framework effectively inhibits in vivo drug-resistant tumor growth and improves survival rates in tumor-bearing mice.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Multidisciplinary Sciences

Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts

Xin Li et al.

Summary: The study demonstrates that co-delivery of indocyanine green and calcipotriol using tumor cell-derived microparticles can enhance the efficacy of photothermal therapy by remodeling the tumor extracellular matrix and improving anti-tumor immune responses.

NATURE COMMUNICATIONS (2022)

Article Engineering, Biomedical

A Cancer Cell Membrane-Derived Biomimetic Nanocarrier for Synergistic Photothermal/Gene Therapy by Efficient Delivery of CRISPR/Cas9 and Gold Nanorods

Lin Huang et al.

Summary: A cancer cell membrane-derived nanocarrier was developed for synergistic photothermal/gene therapy. This nanotherapeutic platform showed high biocompatibility, homologous targeting capacity, and efficient payload delivery, leading to enhanced therapeutic efficacy.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Two-Wave Variable Nanotheranostic Agents for Dual-Mode Imaging-Guided Photo-Induced Triple-Therapy for Cancer

Xiao Sang et al.

Summary: This study proposes a novel nanotheranostic agent for precise tumor imaging and treatment using photothermal therapy. The agent enhances MRI/NIRFI imaging and enables triple-therapy. Photo-induced triple-therapy enhances precision cancer therapy by ablation, blocking tumor cell cycle, and promoting antitumor immunity.

ADVANCED SCIENCE (2022)

Article Engineering, Biomedical

Quercetin-ferrum nanoparticles enhance photothermal therapy by modulating the tumor immunosuppressive microenvironment

Lin Li et al.

Summary: Photothermal therapy (PTT) is limited by the immunosuppressive microenvironment in tumors. A versatile photosensitizer was prepared in this study to enhance the efficacy of PTT by remodeling the tumor microenvironment. The photosensitizer could reduce PD-L1 expression and reshape the extracellular matrix in tumor cells, improving the immunosuppressive microenvironment. Additionally, the photosensitizer could capture tumor antigen and deliver it to the lymph nodes, enhancing the activation of antigen-presenting cells. The PTT based on this photosensitizer eliminated tumors and induced long-term immune memory.

ACTA BIOMATERIALIA (2022)

Article Nanoscience & Nanotechnology

Remotely controlled near-infrared-triggered photothermal treatment of brain tumours in freely behaving mice using gold nanostars

Hamed Arami et al.

Summary: In this study, a wireless near-infrared stimulation-based photothermal approach for the continuous and on-demand treatment of brain tumours in freely moving animals is presented. The method avoids the risks and side-effects associated with open-skull tumour resection and chemotherapy or X-ray radiation. It utilizes an integrated nanomedicine-bioelectronics brain-machine interface, allowing precise treatment of deep brain tumours and selective diffusion of treatment in tumour tissues.

NATURE NANOTECHNOLOGY (2022)

Article Engineering, Biomedical

Amorphous Ultra-Small Fe-Based Nanocluster Engineered and ICG Loaded Organo-Mesoporous Silica for GSH Depletion and Photothermal-Chemodynamic Synergistic Therapy

Jiaqi Li et al.

Summary: Intracellular oxidative amplification is effective in destroying tumor cells, but overexpressed glutathione impairs this effect. Researchers have developed a new nanocarrier that enhances tumor chemodynamic therapy by combining photothermal therapy and glutathione depletion.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity

Miao Fan et al.

Summary: Chemotherapy-induced organ toxicity, specifically hepatotoxicity and cardiotoxicity, is a major cause of death in cancer patients. This study shows that modifying mesenchymal stem cell exosomes with a tetrahedral DNA nanostructure can reduce chemotherapy-induced hepatotoxicity by scavenging the toxic drug. Furthermore, by engineering the exosomes with a cardiomyopathic peptide, they can specifically target cardiomyocytes and alleviate cardiotoxicity, while also promoting macrophage polarization for tissue repair.

ADVANCED SCIENCE (2022)

Article Chemistry, Multidisciplinary

NIR-II Excitation Phototheranostic Platform for Synergistic Photothermal Therapy/Chemotherapy/Chemodynamic Therapy of Breast Cancer Bone Metastases

Pengfei Sun et al.

Summary: This study presents a phototheranostic approach using NIR-II excitation for breast cancer bone metastases. The approach combines NIR-II fluorescence imaging, NIR-II photoacoustic imaging, NIR-II photothermal therapy, chemotherapy, and chemodynamic therapy. The phototheranostic successfully suppresses tumor cell progression in bone tissue and provides insights for the development of NIR-II phototheranostics.

ADVANCED SCIENCE (2022)

Review Chemistry, Multidisciplinary

Organic photosensitizers for antimicrobial phototherapy

Van-Nghia Nguyen et al.

Summary: Microbial infectious diseases, especially those caused by new and antibiotic-resistant bacteria, pose a significant threat to global human health. Phototherapy, as an antibiotic-free treatment, shows promise in treating microbial infections due to its selectivity, non-invasiveness, minimal side effects, and broad antimicrobial activity. This tutorial review provides an overview of the concept and significance of phototherapy, as well as recent research progress in using organic photosensitizers for antimicrobial applications.

CHEMICAL SOCIETY REVIEWS (2022)

Article Chemistry, Multidisciplinary

Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment

Zhan Zhang et al.

Summary: The novel polyphenol-based nanocomplex is designed to induce highly efficacious cancer immunosurveillance, localize therapy on the primary tumor, and minimize systemic side effects. It is prepared via metal-polyphenol coordination by encapsulating natural polyphenol gossypol and a newly synthesized polyphenol derivative polyethylene glycol-Chlorin e6 (Ce6). The nanocomplex can induce chemotherapeutic/photodynamic immunogenic cancer cell death upon laser irradiation, supported by dendritic cell maturation, secretion of inflammatory cytokines, and inhibition of distant untreated tumors.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Lian-Hua Fu et al.

Summary: Chemodynamic therapy (CDT) is a promising method for killing cancer cells by converting intracellular hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals ((OH)-O-center dot). An intelligent nanocatalytic theranostics, PGC-DOX, was developed to address the limitations of endogenous H2O2 and high GSH levels in tumor cells, leading to efficient cancer therapy. The system combines H2O2 self-supply, GSH-elimination, and DOX-induced chemotherapy to effectively inhibit tumor growth with minimal side effects in vivo.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Mixed-Metal MOF-Derived Hollow Porous Nanocomposite for Trimodality Imaging Guided Reactive Oxygen Species-Augmented Synergistic Therapy

Yue Cheng et al.

Summary: This study proposes a trimodality therapy using a mixed-metal MOF composite for synergistic photothermal therapy, photodynamic therapy, and chemodynamic therapy. The composite with hollow structures efficiently integrates multiple functions to enhance treatment efficacy.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

GSH-Depleted Nanozymes with Dual-Radicals Enzyme Activities for Tumor Synergic Therapy

Shengming Wu et al.

Summary: Developing a novel nanocatalyst platform involving longer half-life time ROS is desired to enhance tumor therapy efficacy. Fe3O4-Schwertmannite nanocomposites with triple-effect tumor therapy were successfully constructed, exhibiting remarkable tumor inhibition both in vitro and in vivo. The comprehensive properties of the nanoplatform, including dual-radical production, Fe3O4 nanocrystal mediated PTT, and the BSO mediated GSH depletion, pave a way to constructing a synergic catalytic nanoplatform for efficient tumor therapy.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Supramolecular Macrophage-Liposome Marriage for Cell-Hitchhiking Delivery and Immunotherapy of Acute Pneumonia and Melanoma

Cheng Gao et al.

Summary: A cell-friendly, host-guest chemistry mediated macrophage-liposome conjugate (M-L) has been developed for stable cell-hitchhiking drug delivery targeting inflamed tissues or cancer tissues. This strategy shows potential clinical applications as it does not affect the migratory and invasive behaviors of macrophages and enhances the therapeutic effects of drugs on diseases.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Engineering, Biomedical

Biodegradable Copper-Based Nanoparticles Augmented Chemodynamic Therapy through Deep Penetration and Suppressing Antioxidant Activity in Tumors

Runxiao Zheng et al.

Summary: The CCMZ NPs are designed to enhance CDT efficacy by inhibiting HO-1 activity, depleting GSH, and converting hydrogen peroxide into hydroxyl radical to eliminate tumor cells efficiently.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

Both-In-One Hybrid Bacteria Suppress the Tumor Metastasis and Relapse via Tandem-Amplifying Reactive Oxygen Species-Immunity Responses

Mengchi Sun et al.

Summary: The combination of glucose dehydrogenase-overexpressed non-pathogenic E. coli with chemotherapeutic drug doxorubicin can generate toxic reactive oxygen species, enhancing the antitumor efficacy and boosting immune responses for effective tumor eradication.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Chemistry, Multidisciplinary

Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform

Jiantao Yu et al.

Summary: Recent research has shown that lactate is a major energy source for cells, prompting the development of a new strategy for cancer starvation therapy involving dual deprivation of lactate and glucose. Nanoplatforms are used to co-deliver CHC and GOx in order to achieve this, resulting in enhanced anti-tumor effects both in vitro and in vivo.

ADVANCED SCIENCE (2021)

Article Chemistry, Multidisciplinary

Co-Ferrocene MOF/Glucose Oxidase as Cascade Nanozyme for Effective Tumor Therapy

Chao Fang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Review Engineering, Biomedical

Metal-organic frameworks for stimuli-responsive drug delivery

Ying Wang et al.

BIOMATERIALS (2020)

Article Chemistry, Multidisciplinary

Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy

Bolong Xu et al.

ADVANCED MATERIALS (2020)

Review Biochemistry & Molecular Biology

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Dong Xu et al.

MOLECULES (2019)

Article Chemistry, Multidisciplinary

Programmed Release of Dihydroartemisinin for Synergistic Cancer Therapy using CaCO3 Mineralized Metal-Organic Framework

Xiuyan Wan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Multidisciplinary

Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

Yu-ting Lu et al.

ACTA PHARMACOLOGICA SINICA (2019)

Article Chemistry, Multidisciplinary

Metal Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery

Wen Cai et al.

ADVANCED SCIENCE (2019)

Article Chemistry, Multidisciplinary

Nanomaterial-Based Organelles Protect Normal Cells against Chemotherapy-Induced Cytotoxicity

Ruibo Zhao et al.

ADVANCED MATERIALS (2018)

Article Chemistry, Multidisciplinary

Hollow Nanostars with Photothermal Gold Caps and Their Controlled Surface Functionalization for Complementary Therapies

Ranran Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Article Nanoscience & Nanotechnology

Manganese Oxide-Coated Carbon Nanotubes As Dual-Modality Lymph Mapping Agents for Photothermal Therapy of Tumor Metastasis

Sheng Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Article Anatomy & Morphology

FT-IR, Raman, RRS Measurements and DFT Calculation for Doxorubicin

Gobind Das et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2010)