期刊
NEUROPSYCHOLOGIA
卷 93, 期 -, 页码 229-241出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2016.11.005
关键词
Emotion; Force control; Freezing; Functional symptoms; Cerebellum vermis
资金
- Marie Curie Fellowship
- European Union [BRIDGE 267171]
- Swiss National Centre of Competence in Research for Affective Sciences [NCCR 51NF40-104897]
- Swiss National Science Foundation [SNF 320030-143764]
- Boursiere d'Excellence Grant from University of Geneva
- Leenaards Nested Project Grant
- Ambizione Swiss National Science Foundation [SNF PZ00P3_147997]
- Swiss National Science Foundation (SNF) [PZ00P3_147997] Funding Source: Swiss National Science Foundation (SNF)
Conversion disorder or functional neurological symptom disorder (FND) can affect the voluntary motor system, without an organic cause. Functional symptoms are thought to be generated unconsciously, arising from underlying psychological stressors. However, attempts to demonstrate a direct relationship between the limbic system and disrupted motor function in FND are lacking. We tested whether negative affect would exacerbate alterations of motor control and corresponding brain activations in individuals with FND. Ten patients and ten healthy controls produced an isometric precision-grip contraction at 10% of maximum force while either viewing visual feedback of their force output, or unpleasant or pleasant emotional images (without feedback). Force magnitude was continuously recorded together with change in brain activity using 84121. For controls, force output decayed from the target level while viewing pleasant and unpleasant images. Patients however, maintained force at the target level without decay while viewing unpleasant images, indicating a pronounced effect of negative affect on force output in FND. This emotional modulation of force control was associated with different brain activation patterns between groups. Contrasting the unpleasant with the pleasant condition, controls showed increased activity in the inferior frontal cortex and pre-supplementary motor area, whereas patients had greater activity in the cerebellum (vermis), posterior cingulate cortex, and hippocampus. Engagement of a cerebellar-limbic network in patients is consistent with heightened processing of emotional salience, and supports the role of the cerebellum in freezing responses in the presence of aversive events. These data highlight a possible neural circuit through which psychological stressors elicit defensive behaviour and modulate motor function in FND.
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