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Rand Naffouje et al.
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Yunzhao Chen et al.
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Xiaoai Zhao et al.
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Xu Qian et al.
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Andrea Rizzo et al.
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Jie Yin et al.
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CAD mutations and uridine-responsive epileptic encephalopathy
Johannes Koch et al.
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Targeting nuclear thymidylate biosynthesis
James Chon et al.
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Kristin K. Brown et al.
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Fedra Luciano-Mateo et al.
NUTRIENTS (2017)
CAD mutations and uridine-responsive epileptic encephalopathy
Johannes Koch et al.
BRAIN (2017)
mTOR Signaling in Growth, Metabolism, and Disease (vol 168, pg 960, 2017)
Robert A. Saxton et al.
CELL (2017)
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Xinjian Li et al.
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Silvia Vincenzetti et al.
CURRENT MEDICINAL CHEMISTRY (2016)
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Aaron M. Hosios et al.
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Xinjian Li et al.
NATURE CELL BIOLOGY (2016)
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Issam Ben-Sahra et al.
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Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation
Alex J. Bott et al.
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Zhaoping Qiu et al.
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Lindsey K. Boroughs et al.
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Regulation of mammalian nucleotide metabolism and biosynthesis
Andrew N. Lane et al.
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MYC and metabolism on the path to cancer
Annie L. Hsieh et al.
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Moloy T. Goswami et al.
ONCOTARGET (2015)
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Arindam Saha et al.
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Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis
Patricia Cortazar et al.
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Roland Nilsson et al.
NATURE COMMUNICATIONS (2014)
Regulation of the pentose phosphate pathway in cancer
Peng Jiang et al.
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Issam Ben-Sahra et al.
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Luis A. Carvajal et al.
GENES & DEVELOPMENT (2012)
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Matthew G. Vander Heiden et al.
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Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
Sudha Mannava et al.
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Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase
Frederic D. Sigoillot et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site
Sheng Li et al.
BIOCHEMICAL JOURNAL (2007)
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
R. B. Robey et al.
ONCOGENE (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD
FD Sigoillot et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Pyrimidine pathways in health and disease
M Loffler et al.
TRENDS IN MOLECULAR MEDICINE (2005)
Influence of methionine/valine-depleted enteral nutrition on nucleic acid and protein metabolism in tumor-bearing rats
YC He et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2003)
Cell cycle-dependent regulation of pyrimidine biosynthesis
FD Sigoillot et al.
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De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo
T Dervieux et al.
BLOOD (2002)
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