期刊
NEUROPSYCHOBIOLOGY
卷 73, 期 3, 页码 184-190出版社
KARGER
DOI: 10.1159/000445480
关键词
ACTH secretion; Animal models; Anxiety; CRF1 receptor; Depression; Ether inhalation; Forced swimming; Restraint stress; Vasopressin V-1b receptor
资金
- AFIP
- FAPESP [98/14303-3, 04/12871-7, 15/08098-5, 2013/18897-7]
- CAPES
- Fundacao Butantan
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [15/08098-5, 98/14303-3] Funding Source: FAPESP
Vasopressin and CRH have complementary roles in the secretion of ACTH following different stress modalities. The concomitant use of V-1b and CRF1 receptor antagonists completely inhibits ACTH secretion in response to different stress modalities. The combination of the CRF1 antagonist SSR125543 with the V-1b antagonist SSR149415 effectively suppressed plasma ACTH 1.30 h after injection in rats stressed by ether vapor inhalation for 1 min, restraint stress for 1 h or forced swimming for 5 min. The duration of the effect was also studied. The CRF1 antagonist effectively suppressed ACTH secretion in restraint stress, while the V-1b antagonist was effective against ether inhalation. Both antagonists were necessary to block the forced swimming stress response. SSR125543 induced a prolonged effect and can be used in a model of prolonged HPA axis blockade. (C) 2016 S. Karger AG, Basel
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