期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 8, 页码 1619-1632出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500316
关键词
asymmetric synthesis; biocatalysis; dehydrogenase enzymes; deracemization; dynamic kinetic resolution
资金
- NSF [DMR-1214019]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1214019] Funding Source: National Science Foundation
Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrolled synthesis. This review highlights the particularly auspicious role for dehydrogenase enzymes in this endeavor, with a focus on dynamic reductive kinetic resolutions (DYRKR) to deracemize building blocks, often setting two stereocenters in so doing. The scope and limitations of such dehydrogenase-mediated processes are overviewed, as are future possibilities for the evolution of enzymatic DYRKR.
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