期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 357, 期 13, 页码 2939-2943出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500237
关键词
fluorine; homogeneous catalysis; hydrazones; hypervalent compounds
资金
- French Ministry of Higher Education and Research (MESR)
The copper-catalyzed C(sp(2))-H trifluoromethylation of N,N-disubstituted hydrazones using the Togni reagent is demonstrated to proceed efficiently for aliphatic aldehyde-derived substrates. The success of the reactions relied on the choice of the N, N-diphenylamino group as the terminal hydrazone amino group where N,N-dialkylamino groups were preferred for (hetero)aromatic aldehyde-derived substrates. In addition, the trifluoromethylated N-arylhydrazones are shown to be ideal substrates for Fischer indole synthesis allowing a straightforward, three-step access to 2-trifluoromethylindole derivatives from simple aldehydes.
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