期刊
NEUROPHARMACOLOGY
卷 104, 期 -, 页码 62-75出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2015.08.005
关键词
Astrocyte; Microglia; Oligodendrocyte; Cognition; Dementia; Neurodegeneration; Neuropsychiatric diseases; Purinoceptors; Purinergic signalling
资金
- German Research Council (DFG) [IL-20/19-1, IL-20/21-1]
- Sino-German Centre for the Promotion of Science [GZ 919]
- Ministry of Education and Science of Russian Federation [02.B.49.21.0003]
- Lobachevsky State University of Nizhny Novgorod [02.B.49.21.0003]
- Russian Scientific Foundation [14-15-00633]
Neuroglia, represented by astrocytes, oligodendrocytes, NG glia and microglia are homeostatic, myelinating and defensive cells of the brain. Neuroglial cells express various combinations of purinoceptors, which contribute to multiple intercellular signalling pathways in the healthy and diseased nervous system. Neurological diseases are invariably associated with profound neuroglial remodelling, which is manifest by reactive gliosis, pathological remodelling and functional atrophy of various types of glial cells. Gliopathology is disease and region specific and produces multiple glial phenotypes that may be neuroprotective or neurotoxic. In this review we summarise recent knowledge on the role of glial purinergic signalling in cognitive-related neurological diseases. This article is part of the Special Issue entitled 'Purines in Neurodegeneration and Neuroregeneration'. (C) 2015 Elsevier Ltd. All rights reserved.
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