Protective role of zinc oxide nanoparticles in alleviating flumethrin-induced hepatic and renal toxicity in male albino rats

ObjectivesZinc oxide nanoparticles (ZnO-NPs) are now well known as antioxidants that have been linked to a relief of oxidative stress induced by several xenobiotics. The objective of this research was to assess the efficacy of ZnO-NPs against flumethrin-induced hepatorenal toxicity in adult male albino rats.MethodsX-ray diffraction was used to characterize ZnO-NPs produced by the grinding ball milling technique. Forty adult male albino rats were separated into four equal groups: the control negative group, which received vehicle (saline); the control positive group, which received flumethrin (10mg/kg body weight); the ZnO-NPs group (15 mg/kg body weight); and the fourth group, which received both flumethrin and ZnO-NPs. The drugs were given orally by using stomach gavage once daily for 60 days. Blood, serum, liver and kidney tissue samples were taken for further analysis.ResultsSignificant adverse effects of flumethrin include decreased serum levels of total antioxidant capacity, reduced liver and kidney functions and an abnormal histological changes of both the liver and kidney. Lower gene expression patterns and down-regulations for TNF-& alpha; and IL-1B in both liver and kidney supported these results. The adverse effects of flumethrin were alleviated in ZnO-NPs/flumethrin-treated group.ConclusionZnO-NPs are ideal candidates for reducing the oxidative stress caused by flumethrin at the serum and genomic levels.

Automated summary

This study assessed the efficacy of ZnO-NPs against flumethrin-induced hepatorenal toxicity in adult male albino rats. The results showed that flumethrin had significant adverse effects, including decreased antioxidant capacity, impaired liver and kidney functions, and abnormal histological changes. However, these adverse effects were alleviated in the ZnO-NPs/flumethrin-treated group.