期刊
NEUROPHARMACOLOGY
卷 110, 期 -, 页码 574-585出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2016.06.014
关键词
Oligodendrocyte; Myelination; Remyelination; Glutamate; Oligodendrocyte precursor cell; Neuronal activity; Proliferation; Differentiation
资金
- Lister Institute of Preventive Medicine
- Wellcome Trust [091543/Z/10/Z]
- MRC [DTG RG64862, 1004208]
- Wellcome Trust [091543/Z/10/Z] Funding Source: Wellcome Trust
- MRC [G0701476] Funding Source: UKRI
- Medical Research Council [MC_PC_12009, 1233560, 1004208] Funding Source: researchfish
Myelin is essential for the mammalian brain to function efficiently. Whilst many factors have been associated with regulating the differentiation of oligodendroglia and myelination, glutamate signalling might be particularly important for learning-dependent myelination. The majority of myelinated projection neurons are glutamatergic. Oligodendrocyte precursor cells receive glutamatergic synaptic inputs from unmyelinated axons and oligodendrocyte lineage cells express glutamate receptors which enable them to monitor and respond to changes in neuronal activity. Yet, what role glutamate plays for oligodendroglia is not fully understood. Here, we review glutamate signalling and its effects on oligodendrocyte lineage cells, and myelination in health and disease. Furthermore, we discuss whether glutamate signalling between neurons and oligodendroglia might lay the foundation to activity-dependent white matter plasticity. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'. (C) 2016 Elsevier Ltd. All rights reserved.
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