期刊
NEUROPEPTIDES
卷 56, 期 -, 页码 19-24出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.npep.2015.11.004
关键词
Intranasal; Resilience; PTSD; Depression; Single prolonged stress
资金
- U.S. Army, Department of Defense Medical Research and Development Program [DM102281]
- CDMRP [DM102281, 545735] Funding Source: Federal RePORTER
There is extensive evidence that NPY in the brain can modulate the responses to stress and play a critical role in resistance to, or recovery from, harmful effects of stress. Development of PTSD and comorbid depression following exposure to traumatic stress are associated with low NPY. This review discusses putative mechanisms for NPY's anti-stress actions. Recent preclinical data indicating potential for intranasal delivery of NPY to brain as a promising non-invasive strategy to prevent a variety of neuroendocrine, molecular and behavioral impairments in PTSD model are summarized. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据