期刊
NEURON
卷 92, 期 6, 页码 1308-1323出版社
CELL PRESS
DOI: 10.1016/j.neuron.2016.11.025
关键词
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资金
- National Institutes of Health - Office of Research Infrastructure Programs [P40 OD010440]
- James Hudson Brown - Alexander Brown Coxe Postdoctoral Fellowships in the Medical Sciences
- Department of Genetics Research Fellowship from Yale University
- NIH [R01NS098817, R01NS094219, R56AG050969]
Axon regeneration is essential to restore the nervous system after axon injury. However, the neuronal cell biology that underlies axon regeneration is incompletely understood. Here we use in vivo, single-neuron analysis to investigate the relationship between nerve injury, mitochondrial localization, and axon regeneration. Mitochondria translocate into injured axons so that average mitochondria density increases after injury. Moreover, single-neuron analysis reveals that axons that fail to increase mitochondria have poor regeneration. Experimental alterations to axonal mitochondrial distribution or mitochondrial respiratory chain function result in corresponding changes to regeneration outcomes. Axonal mitochondria are specifically required for growth-cone migration, identifying a key energy challenge for injured neurons. Finally, mitochondrial localization to the axon after injury is regulated in part by dual-leucine zipper kinase 1 (DLK-1), a conserved regulator of axon regeneration. These data identify regulation of axonal mitochondria as a new cell-biological mechanism that helps determine the regenerative response of injured neurons.
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