期刊
CHEMICAL SOCIETY REVIEWS
卷 44, 期 17, 页码 6258-6286出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cs00511b
关键词
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资金
- National Nature Science Foundation of China [51102259, 31271021, 31222023]
- Distinguished Young Scholars of Sichuan University [2011SCU04B18]
- Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Metastasis is deadly and also tough to treat as it is much more complicated than the primary tumour. Anti-metastasis approaches available so far are far from being optimal. A variety of nanomedicine formulae provide a plethora of opportunities for developing new strategies and means for tackling metastasis. It should be noted that individualized anti-metastatic nanomedicines are different from common anti-cancer nanomedicines as they specifically target different populations of malignant cells. This review briefly introduces the features of the metastatic cascade, and proposes a series of nanomedicine-based anti-metastasis strategies aiming to block each metastatic step. Moreover, we also concisely introduce the advantages of several promising nanoparticle platforms and their potential for constructing state-of-the-art individualized anti-metastatic nanomedicines.
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