期刊
CHEMICAL SOCIETY REVIEWS
卷 44, 期 15, 页码 5495-5551出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cs00048c
关键词
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资金
- SATT Conectus BioReLiable project, CNRS, University of Strasbourg
- International Center for Frontier Research in Chemistry (icFRC)
Bioconjugation methodologies have proven to play a central enabling role in the recent development of biotherapeutics and chemical biology approaches. Recent endeavours in these fields shed light on unprecedented chemical challenges to attain bioselectivity, biocompatibility, and biostability required by modern applications. In this review the current developments in various techniques of selective bond forming reactions of proteins and peptides were highlighted. The utility of each endogenous amino acid-selective conjugation methodology in the fields of biology and protein science has been surveyed with emphasis on the most relevant among reported transformations; selectivity and practical use have been discussed.
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