期刊
NEURON
卷 91, 期 4, 页码 837-850出版社
CELL PRESS
DOI: 10.1016/j.neuron.2016.07.029
关键词
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资金
- Centre National de la Recherche Scientifique
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche [ANR-2010-BLANC-1411, ANR-13-BSV4-0016]
- Ile de France (Domaine d'Interet Majeur MALINF)
- Investissements d'Avenir [ANR-11-IDEX-0004-02]
- Swedish Research Council
- Ecole des Neurosciences de Paris, an EMBO Long-Term Fellowship [1582-2011]
- Roux-Howard-Cantarini post-doctoral fellowship
- Marie Curie Individual Fellowship within European Community [301362]
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV4-0016] Funding Source: Agence Nationale de la Recherche (ANR)
Dendritic voltage integration determines the transformation of synaptic inputs into output firing, while synaptic calcium integration drives plasticity mechanisms thought to underlie memory storage. Dendritic calcium integration has been shown to follow the same synaptic input-output relationship as dendritic voltage, but whether similar operations apply to neurons exhibiting sublinear voltage integration is unknown. We examined the properties and cellular mechanisms of these dendritic operations in cerebellar molecular layer interneurons using dendritic voltage and calcium imaging, in combination with synaptic stimulation or glutamate uncaging. We show that, while synaptic potentials summate sublinearly, concomitant dendritic calcium signals summate either linearly or supralinearly depending on the number of synapses activated. The supralinear dendritic calcium triggers a branch-specific, short-term suppression of neurotransmitter release that alters the pattern of synaptic activation. Thus, differential voltage and calcium integration permits dynamic regulation of neuronal input-output transformations without altering intrinsic nonlinear integration mechanisms.
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