期刊
NEURON
卷 90, 期 3, 页码 622-634出版社
CELL PRESS
DOI: 10.1016/j.neuron.2016.03.019
关键词
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资金
- Howard Hughes Medical Institute International Student Research Fellowship
- NSERC PGS M award
- NSERC PGS D award
- McKnight Memory and Cognitive Disorders Award
- Human Frontiers Science Program
- Brain and Behavior Research Foundation
- National Institute of Mental Health (NIMH) [1R01MH100631]
- National Institute of Neurological Disorders and Stroke (NINDS) [1U01NS090583]
We present a model for neural circuit mechanisms underlying hippocampal memory. Central to this model are nonlinear interactions between anatomically and functionally segregated inputs onto dendrites of pyramidal cells in hippocampal areas CA3 and CA1. We study the consequences of such interactions using model neurons in which somatic burstfiring and synaptic plasticity are controlled by conjunctive processing of these separately integrated input pathways. We find that nonlinear dendritic input processing enhances the model's capacity to store and retrieve large numbers of similarmemories. During memory encoding, CA3 stores heavily decorrelated engrams to prevent interference between similar memories, while CA1 pairs these engrams with information-rich memory representations that will later provide meaningful output signals during memory recall. While maintaining mathematical tractability, this model brings theoretical study of memory operations closer to the hippocampal circuit's anatomical and physiological properties, thus providing a framework for future experimental and theoretical study of hippocampal function.
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