期刊
NEUROMUSCULAR DISORDERS
卷 26, 期 7, 页码 414-422出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nmd.2016.04.009
关键词
Imaging biomarker; Dystrophinopathy; Becker muscular dystrophy; Quantitative MR; Timed function tests
资金
- Lorenzo Paiggio Foundation
- Swiss Foundation for Research on Muscle Diseases (SSEM)
- Asscociation Suisse Romande Intervenant contre les Maladies neuro-Musculaires (ASRIMM)
- Swiss Muscle Society
- Swiss network for Translational Research in Europe for the Assessment and Treatment of Neuromuscular Disease (TREAT-NMD)
- German network for Translational Research in Europe for the Assessment and Treatment of Neuromuscular Disease (TREAT-NMD)
- Thomi-Hopf-Stiftung
Becker muscular dystrophy (BMD) has an incidence of 1 in 16 000 male births. This cross-sectional study investigated the relation between validated functional scores and quantitative MRI (qMRI) of thigh muscles in 20 ambulatory BMD patients, aged 18.3-60 years (mean 31.2; SD 11.1). Clinical assessments included the motor function measure (MFM) and its subscales, as well as timed function tests such as the 6-minute walk test (6MWT) and the timed 10-m run/walk test. Quantitative MRI of the thigh muscles included the mean fat fraction (MFF) using a 2-point Dixon (2-PD) technique, and transverse relaxation time (T2) measurements. The mean MFM value was 80.4%, SD 9.44 and the D1 subscore 54.5%, SD 19.9. The median 6MWT was 195m, IQR 160-330.2. The median 10-m run/walk test was 7.4 seconds, IQR 6.1-9.3. The mean fat fraction of the thigh muscles was 55.6%, SD 17.4%, mean T2 relaxation times of all muscles: 69.9 ms, SD 14.4. The flexors had the highest MFF and T2 relaxation times, followed by the extensors and the adductors. MFF and global T2 relaxation times were highly negatively correlated with the MFM total, Dl-subscore and 6MWT, and positively correlated with the 10 m run/walk test time (p < 0.01). Age was not correlated with MIT, global T2 relaxation time or clinical assessments. Both MFF and T2 measures in the thigh muscle were well correlated with clinical function in BMD and may serve as a surrogate outcome measure in clinical trials. (C) 2016 Elsevier B.V. All rights reserved.
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