3.8 Article

Synthesis, Crystal Structure and Anti-Leukemic Activity of (E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells

Guanglong Zhang et al.

Summary: A new series of 2-chloro-N-(5-(2-oxoindolin-3-yl)-4H-pyrazol-3-yl) acetamide derivatives containing 1,3,4-thiadiazole and 4H-1,2,4-triazol-4-amine moiety were designed and synthesised as novel anticancer agents. Compound 10b showed the highest antiproliferative activity with IC50 values of 12.0 nM and 10 nM against A549 and K562 cells, respectively. Mechanism investigation and docking studies revealed that 10b exhibited apoptosis characteristic, dose-dependent growth arrest, and modulation of EGFR and p53-MDM2 mediated pathway.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2023)

Article Biochemistry & Molecular Biology

Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors

Yongfang Yao et al.

Summary: This article reports the effects of the screened DYT-1 compound from an in-house library on inhibiting tubulin polymerisation, anti-angiogenesis, and anti-leukaemia proliferation in vitro and in vivo. Further investigation led to the discovery of compound 29e, which displayed excellent activity in tubulin and zebrafish assays, and nanomolar potency against a variety of leukaemia cell lines. Compound 29e stably binds to the tubulin colchicine site, showing promising anti-angiogenesis and anti-leukaemia effects. These results suggest that 29e could be considered as an effective anti-angiogenesis and anti-leukaemia drug candidate.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)

Article Chemistry, Organic

Synthesis, Crystal Structure and Anti-Leukemic Activity of 1,3-Dihydro-1-{1-[4-(4-phenylpyrrolo [1,2-a]quinoxalin-3-yl)benzyl]piperidin-4-yl}-2H-benzimidazol-2-one

Jean Guillon et al.

Summary: A new substituted pyrroloquinoxaline compound was synthesized and its structure was characterized using various analytical techniques. This compound exhibited interesting cytotoxic potential against multiple human leukemia cell lines.

MOLBANK (2022)

Review Chemistry, Organic

New achievements in the synthesis of pyrrolo[1,2-a]quinoxalines

Alexey A. Kalinin et al.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2019)

Article Chemistry, Medicinal

Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold

Ting Wang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Biochemistry & Molecular Biology

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a] quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives

Jean Guillon et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

Article Chemistry, Medicinal

Design, Synthesis and Antimalarial Activity of Some New Aminoalcohol-pyrrolo[1,2-a]quinoxaline Derivatives

Jean Guillon et al.

LETTERS IN DRUG DESIGN & DISCOVERY (2016)

Review Chemistry, Medicinal

Recent Progress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines

Aiping Huang et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2013)

Article Chemistry, Medicinal

New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: Synthesis, and in vitro antimalarial activity - Part II

Jean Guillon et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II

Vanessa Desplat et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives:: Synthesis, and in vitro antimalarial activity

Jean Guillon et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Synthesis of new pyrrolo[1,2-a]quinoxaline derivatives as potential inhibitors of Akt kinase

Vanessa Desplat et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2008)

Article Chemistry, Multidisciplinary

A short history of SHELX

George M. Sheldrick

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (2008)

Article Biochemistry & Molecular Biology

Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents

Jean Guillon et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Synthesis of new 4-(E)-alkenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents by Suzuki-Miyaura cross-coupling reactions

Jean Guillon et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2007)