3.8 Article

NARYLSULFONYL-2-AROYLAMINO-1,4- QUINONE IMINES AND THEIR HYDROGENATED ANALOGUES: PREDICTION OF TOXICITY AND PROSPECTS FOR USE AS DIURETICS

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Article Medicine, General & Internal

DESIGN AND SEARCH FOR PROSPECTIVE DIURETICS (CA II INHIBITORS) AMONG AROYLHYDRAZONES OF ESTERS QUINONE OXIME USING IN SILICO AND IN VIVO METHODOLOGY

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Summary: The design and search for new selective inhibitors of CA II with minimal electrolyte disturbances is an urgent problem in medical chemistry and pharmacology. This study identified and characterized potential diuretics among a group of compounds and found an effective compound that exceeds the effects of the comparison drug in terms of diuretic effect.

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