期刊
NEUROLOGY
卷 86, 期 9, 页码 821-828出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000002413
关键词
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资金
- Wellcome Trust-GlaxoSmithKline Translational Medicine Training Programme
- Imperial College Healthcare Trust Biomedical Research Centre
- MRC PET programme grant [G1100809/1]
- MS Society of Great Britain
- Progressive MS Alliance
- MRC
- GlaxoSmithKline
- National Institute for Health Research
- Medical Research Council (UK)
- MRC [G1100809, MC_U120085814, MR/L022141/1, G0900897, MC_U120036861, G1100810, G0701951] Funding Source: UKRI
- Medical Research Council [MR/L022141/1, MC_U120085814, MC_U120036861, G1100809, G1100810, G0701951, G0900897] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0514-10022, NIHR-RP-011-048] Funding Source: researchfish
Objective:To image -amyloid (A) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic axonal injury and A are correlated, and compare the spatial distribution of A to Alzheimer disease (AD).Methods:Patients 11 months to 17 years after moderate-severe TBI underwent C-11-Pittsburgh compound B (C-11-PiB)-PET, structural and diffusion MRI, and neuropsychological examination. Healthy aged controls and patients with AD underwent PET and structural MRI. Binding potential (BPND) images of C-11-PiB, which index A plaque density, were computed using an automatic reference region extraction procedure. Voxelwise and regional differences in BPND were assessed. In TBI, a measure of white matter integrity, fractional anisotropy, was estimated and correlated with C-11-PiB BP(ND.)Results:Twenty-eight participants (9 with TBI, 9 controls, 10 with AD) were assessed. Increased C-11-PiB BPND was found in TBI vs controls in the posterior cingulate cortex and cerebellum. Binding in the posterior cingulate cortex increased with decreasing fractional anisotropy of associated white matter tracts and increased with time since injury. Compared to AD, binding after TBI was lower in neocortical regions but increased in the cerebellum.Conclusions:Increased A burden was observed in TBI. The distribution overlaps with, but is distinct from, that of AD. This suggests a mechanistic link between TBI and the development of neuropathologic features of dementia, which may relate to axonal damage produced by the injury.
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