期刊
JOURNAL OF RHEUMATIC DISEASES
卷 30, 期 4, 页码 260-267出版社
KOREAN COLL RHEUMATOLOGY
DOI: 10.4078/jrd.2023.0032
关键词
Hepatic steatosis index; End-stage renal disease; Antineutrophil cytoplasmic antibody; Vasculitis; Forecasting
类别
This study found that the hepatic steatosis index (HSI) at diagnosis of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can predict poor outcomes during the disease course, especially the increased risk of end-stage renal disease (ESRD).
Objective: This study evaluated whether the hepatic steatosis index (HSI) at antineutrophil cytoplasmic antibody-associated vas-culitis (AAV) diagnosis could forecast poor outcomes during the disease course in AAV patients.Methods: This study included 260 AAV patients. The equation for HSI is as follows: HSI=8x(alanine aminotransferase/aspartate aminotransferase)+body mass index+(2, diabetes mellitus)+(2, female). The cut-off of HSI was obtained using the receiver operating characteristic curve.Results: The median age of the 260 patients was 59.5 years, and 65.0% were female. Among the continuous variables excluding the parameters composing the equation for HSI, HSI was significantly correlated with Birmingham vasculitis activity score, five-factor score, haemoglobin, blood urea nitrogen, serum creatinine, and total cholesterol. Among poor outcomes, the area under the curve of HSI for end-stage renal disease (ESRD) was significant, and the cut-off of HSI for ESRD was set at <= 30.82. AAV patients with HSI <= 30.82 exhibited a significantly higher risk of ESRD (relative risk 3.489) and a significantly lower cumulative ESRD-free survival rate than those with HSI >30.82.Conclusion: This study is the first to demonstrate that HSI at AAV diagnosis could forecast ESRD during the disease course in AAV patients.
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