High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update

Article Immunology

High-dose influenza vaccines for the prevention of hospitalization due to cardiovascular events in older adults in the nursing home: Post-hoc analysis of a cluster-randomized trial

Elie A. Saade et al.

VACCINE (2022)

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Article Public, Environmental & Occupational Health

Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022–23 Influenza Season

Lisa A. Grohskopf et al.

MMWR Recommendations and Reports (2022)

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Article Immunology

Comparing the impact of high-dose versus standard dose influenza vaccines on hospitalization cost for cardiovascular and respiratory diseases: Economic assessment in the US Veteran population during 5 respiratory seasons using an instrumental variable method

Robertus van Aalst et al.

Summary: In a study conducted in the US VHA population, high-dose influenza vaccination was found to significantly reduce hospitalization risks for cardiovascular and respiratory diseases. Reduction in hospitalizations for cardiovascular diseases contributed more to cost savings per high-dose recipient compared to respiratory diseases.

VACCINE (2021)

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Article Immunology

Comparative Effectiveness of Influenza Vaccines Among US Medicare Beneficiaries Ages 65 Years and Older During the 2019-2020 Season

Hector S. Izurieta et al.

Summary: In this study, we analyzed the relative vaccine effectiveness of different types of influenza vaccines in preventing hospital encounters among Medicare beneficiaries aged >= 65 years during the 2019-2020 season. The results showed that recombinant quadrivalent vaccine was moderately more effective than other vaccines during the season, while high-dose trivalent and adjuvanted trivalent vaccines were more effective than quadrivalent vaccines, emphasizing the contributions of antigen amount and adjuvant use to vaccine effectiveness.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease A Randomized Clinical Trial

Orly Vardeny et al.

Summary: In patients with high-risk cardiovascular disease, high-dose trivalent inactivated influenza vaccine did not significantly reduce all-cause mortality or cardiopulmonary hospitalizations compared with standard-dose quadrivalent inactivated influenza vaccine, but influenza vaccination remains strongly recommended in this population.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Immunology

Efficacy and effectiveness of high-dose influenza vaccine in older adults by circulating strain and antigenic match: An updated systematic review and meta-analysis

Jason K. H. Lee et al.

Summary: Evidence over 10 consecutive influenza seasons and in more than 34 million individuals aged >= 65 years suggests that HD-IIV3 is consistently more effective than SD-IIV at reducing influenza cases as well as influenza-associated clinical complications irrespective of circulating strain and antigenic match.

VACCINE (2021)

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Article Infectious Diseases

Prevention of influenza during mismatched seasons in older adults with an MF59-adjuvanted quadrivalent influenza vaccine: a randomised, controlled, multicentre, phase 3 efficacy study

Jiri Beran et al.

Summary: The study aimed to investigate the clinical efficacy of MF59-adjuvanted quadrivalent influenza vaccine in adults aged 65 and older. The vaccine efficacy was higher against influenza cases associated with higher fever, but did not meet the preset standard in seasons with high amounts of vaccine strain mismatch.

LANCET INFECTIOUS DISEASES (2021)

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Article Microbiology

Choice of influenza vaccine in people over 65 years old. Analysis of reports from international vaccination advisory committees

Alberto Perez-Rubio et al.

Summary: The study analyzed the annual recommendations on influenza vaccine use for the population over 65 years of age, including the recommended vaccine types by different advisory committees in various countries, such as Quadrivalent Inactivated Influenza Vaccine with Adjuvant, High Dose Quadrivalent Inactivated Influenza Vaccine, etc. It is generally recommended to use enhanced immunity vaccines in the population over 65 years of age.

REVISTA ESPANOLA DE QUIMIOTERAPIA (2021)

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Article Immunology

Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons

Marina Amaral de Avila Machado et al.

Summary: The study compared the effectiveness of different influenza vaccines in seniors, finding that SD quadrivalent vaccine and SD trivalent vaccine were associated with a higher risk of hospitalization or ER visit for influenza and pneumonia compared to HD trivalent vaccine. Risk estimates varied slightly across seasons.

NPJ VACCINES (2021)

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Article Immunology